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EC number: 236-828-6
CAS number: 13501-76-3
Oral (OECD TG 401), rat: LD50 > 2000 mg/kg bw (limit test)Dermal: (OECD TG 402), rat: LD50 > 2000 mg/kg bw (limit test) Inhalation: No measured data are available.
were chosen as key when the available study was of relevance and of
sufficient quality for classification, labelling and for risk
key acute oral limit test which was conducted in compliance with GLP and
according to the now deleted OECD TG 401 is available on
(3-chloropropyl)diethoxymethylsilane. Two out of five males died when
dosed at 2000 mg/kg bw and the macroscopic examination of the two
perished animals showed the most severe lesions in the stomach and the
intestine. The mucosa of these tissues showed hyperaemia and
haemorrhages. No macroscopic abnormalities were observed in animals
killed on day 14. All animals showed severe clinical symptoms in the
first six hours after treatment with the test substance. The symptoms
seen were padding movements, gait abnormality; decreased activity and
squatting position. 24 and 48 hours after treatment most of the animals
showed still the described clinical signs. Only one male and one female
showed these signs 72 hours after treatment with the test substance.
Milder clinical signs like piloerection were observed until day 7. After
7 days until the end of the observation period there were no more signs
of systemic reaction to treatment. The LD50to rats of
(3-Chloropropyl)diethoxymethylsilane was found to be > 2000 mg/kg bw
(Hüls AG, 1997a).
key acute dermal toxicity study which was conducted in compliance with
GLP and according to OECD TG 402 is available on
(3-chloropropyl)diethoxymethylsilane, there was no mortality or any
systemic effects seen at 2000 mg/kg bw (24 hour exposure). (LD0and
LD50> 2000 mg/kg bw) (Hüls AG, 1997b).
There are no inhalation data available.
available data on acute toxicity of the registered substance do not meet
the criteria for classification according to Regulation 1272/2008 or EU
Directive 67/548/EEC, and are therefore conclusive but not sufficient
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