Registration Dossier
Registration Dossier
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EC number: 236-828-6 | CAS number: 13501-76-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Endpoint summary
Administrative data
Description of key information
Oral (OECD TG 401), rat: LD50 > 2000 mg/kg bw (limit test)
Dermal: (OECD TG 402), rat: LD50 > 2000 mg/kg bw (limit test)
Inhalation: No measured data are available.
Key value for chemical safety assessment
Acute toxicity: via oral route
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Quality of whole database:
- The study was conducted according to the appropriate OECD test guideline, and in compliance with GLP.
Acute toxicity: via inhalation route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Acute toxicity: via dermal route
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Quality of whole database:
- The study was conducted according to the appropriate OECD test guideline, and in compliance with GLP.
Additional information
Studies were chosen as key when the available study was of relevance and of sufficient quality for classification, labelling and for risk assessment.
A key acute oral limit test which was conducted in compliance with GLP and according to the now deleted OECD TG 401 is available on (3-chloropropyl)diethoxymethylsilane. Two out of five males died when dosed at 2000 mg/kg bw and the macroscopic examination of the two perished animals showed the most severe lesions in the stomach and the intestine. The mucosa of these tissues showed hyperaemia and haemorrhages. No macroscopic abnormalities were observed in animals killed on day 14. All animals showed severe clinical symptoms in the first six hours after treatment with the test substance. The symptoms seen were padding movements, gait abnormality; decreased activity and squatting position. 24 and 48 hours after treatment most of the animals showed still the described clinical signs. Only one male and one female showed these signs 72 hours after treatment with the test substance. Milder clinical signs like piloerection were observed until day 7. After 7 days until the end of the observation period there were no more signs of systemic reaction to treatment. The LD50to rats of (3-Chloropropyl)diethoxymethylsilane was found to be > 2000 mg/kg bw (Hüls AG, 1997a).
A key acute dermal toxicity study which was conducted in compliance with GLP and according to OECD TG 402 is available on (3-chloropropyl)diethoxymethylsilane, there was no mortality or any systemic effects seen at 2000 mg/kg bw (24 hour exposure). (LD0and LD50> 2000 mg/kg bw) (Hüls AG, 1997b).
There are no inhalation data available.
Justification for selection of acute toxicity – oral endpoint
The key study was selected for assessment.
Justification for selection of acute toxicity – inhalation endpoint
In accordance with Column 2 of REACH Annex VIII, the acute toxicity study via the inhalation route (required in Section 8.5.2) does not need to be conducted as reliable data via the oral and dermal routes are available.
Justification for selection of acute toxicity – dermal endpoint
The key study was selected for assessment.
Justification for classification or non-classification
The available data on acute toxicity of the registered substance do not meet the criteria for classification according to Regulation 1272/2008 or EU Directive 67/548/EEC, and are therefore conclusive but not sufficient for classification.
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