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EC number: 236-828-6
CAS number: 13501-76-3
Skin irritation (OCED TG 404): irritating Eye irritation (OECD TG 405): not irritating
were chosen as key when the available study was of relevance and of
sufficient quality for classification, labelling and for risk
key skin irritation study which was conducted according to OECD TG 404
and GLP, showed that (3-chloropropyl)diethoxymethylsilane was irritating
to the skin of small white Russian rabbits. 30-60 minutes after removal
of the dressing’s two rabbits had grade 2 erythema and edema, and one
had grade 1 erythema and edema. After 24 and 48 hours the irritation had
worsened so that the erythma was grade 2 and 3 and the edema was grade 2
and 4. The irritation then gradually reversed until there were no signs
of erythema and edema on day 10. Yellow skin discolouration in animal 1
after 24 and 48 hours was observed. Dry or flaky skin in all animals
after about a week was also observed. It
was therefore concluded that (3-chloropropyl)diethoxymethylsilane was
irritating to rabbit skin (Hüls
A key eye
irritation study which was conducted to OECD TG 405 and GLP, showed that
(3-chloropropyl)diethoxymethylsilane was only very slightly irritating
to the eyes of small white Russian rabbits and therefore was not
classified as an eye irritant. Within one hour of instillation there was
some redness and edema of the conjunctiva. By 24 and 48 hours after
instillation there was some redness, but no edema. At 72 hours there
were no signs of irritation remaining. It was therefore concluded that
(3-chloropropyl)diethoxymethylsilane was not an eye irritant (Hüls AG,
the available study for skin irritation,
(3-chloropropyl)diethoxymethylsilane needs to be classified as R38
‘’irritating to skin’’ according to the criteria of EU Directive
67/548/EEC, and Skin Irritant Category 2 under Regulation 1272/2008.
available data on eye irritation of the registered substance do not meet
the criteria for classification according to Regulation (EC) 1272/2008
or Directive 67/548/EEC, and are therefore conclusive but not sufficient
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