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EC number: 236-828-6
CAS number: 13501-76-3
EC10/LC10 or NOEC for aquatic micro-organisms: 1000 mg/L
There are no microorganism toxicity data available for (3
chloropropyl)diethoxymethylsilane, therefore, good quality data for the
structurally-related substance, (chloromethyl)triethoxysilane (CAS
015267-95-5), have been read across. Both substances hydrolyse to
structurally-related silanol hydrolysis products. It is therefore
considered valid to read-across the results for
(chloromethyl)triethoxysilane (CAS 015267-95-5) to fill the data gap for
the registered substance.Additional information is given in a supporting
report (PFA, 2013m) attached in Section 13 of the IUCLID 5 dossier.
Both (3 chloropropyl)diethoxymethylsilane and
(chloromethyl)triethoxysilane are within an analogue group of substances
that exhibit no evidence of significant toxicity to microorganisms.
It is therefore considered valid to read-across the results
for(chloromethyl)triethoxysilaneto fill the data gap for the registered
Table 7.4.1 presents microorganism toxicity data available for
substances within the analogue group (III-15) of chlorosilanes,
siloxanes, silanes and alkoxysilanes etc, with chloroalkyl functional
group(s) in side chain after any very rapid hydrolysis has been
Table7.4.2 Microorganism toxicity data available for substances
within the relevant sub-class (III-15) of chemicals
Result: E(I)C50 (mg/l)
Result: NOEC (or EC10/ EC20) (mg/l)
EC10 1.1 ml/lNote: WS predicted 14000
EC10 >2 ml/l
An EC50of >1000 mg/l and a NOEC of 1000 mg/l for
toxicity to microorganisms were determined in a reliable study conducted
according to an appropriate test protocol, and in compliance with GLP
OECD Guideline 209 (Activated Sludge, Respiration Inhibition Test,
NOTOX, 2011). Additional information are available for
(3-chloropropyl)triethoxysilane (CAS 5089-70-3) as supporting
information to (3-chloropropyl)diethoxymethylsilane (CAS 13501-76-3)
because they are structurally-related substances and they have similar
hydrolysis half-lives. A 5 h EC10value of 2000 µl/l was
determined for toxicity to microorganisms (Pseudomonas putida).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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