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EC number: 406-420-4
CAS number: 69430-40-6
TOXICITY OF THE TEST SUBSTANCE
The survival of the TA100 culture is determined by comparing the number
of colonies on the plates containing the test substance with those on
the solvent control plate. Both in the absence and presence of S9-mix
the survival of strain TA100 is not reduced up to test substance
concentrations of 5000 µg/plate. Based on these data, the test substance
was tested up to a concentration of 5000 µ/plate in the absence and
presence of S9-mix.
THE AMES SALMONELLA/MICROSOME PLATE TEST
All bacterial strains showed negative responses over the entire dose
range of the test substance, i.e. no dose-related, two-fold, increase in
the number of revertants in two independently repeated experiments. The
negative and strain-specific positive control values fell within our
laboratory background historical ranges indicating that the test
conditions were optimal and that the metabolic activation system
Based on the results of this study it is concluded that the test
substance can be considered as not mutagenic in the Ames
DC5067 was tested in the Ames Salmonella/microsome plate test up to 5000
µg/plate in the absence and presence of S9-mix. The test substance did
not induce a dose-related increase in the number of revertant (His+)
colonies in each of the four tester strains (TA1535; TA1537; TA9B and
TAl00). These results were confirmed in an independently repeated
experiment. The test substance can, therefore, be considered as not
mutagenic in this test system.
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