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EC number: 406-420-4
CAS number: 69430-40-6
Instillation of DC 5067 into one of the eyes of each of three albino
rabbits affected the conjunctivae of all animals. The irritation of the
conjunctivae was reversible within 48 hours in all animals. Treatment of
the eyes with 2% fluorescein, 24 hours after test substance instillation
revealed no cornea1 epithelial damage in all of the animals.
No staining by the test substance was observed.
There was no evidence of ocular corrosion.
Toxic Symptoms / Mortality:
No toxic symptoms were observed in the animals during the test period
and no mortality occured.
The purpose of this study was to assess the possible irritation or
corrosion potential of DC5067 when a single dose of DC5067 was placed in
the conjunctival sac of a rabbit eye.
This study was carried out in accordance with OECD Guideline Number 405,
"Acute Eye Irrittion/Corrosion" and EEC Directive 84/449/EEC, Part B.5,
"Acute Toxicity-Eye Irritation". DC5067 was instilled in one of the eyes
of each of three female rabbits, followed by four observations at
approximately 1, 24, 48, and 72 hours after test article administration.
Under the conditions of this study, DC5067 resulted in adverse effects
of the conjunctivae in all three animals. The irritation of the
conjunctivae was reversible within 48 hours in all animals. No ocular
corrosion was observed in any of the animals. No signs of systemic
intoxication were observed during the study period.
The test substance should be considered minimally irritating (Ml) to the
rabbit eye (Kay and Calandra interpretation of the Draize score: 3.3).
According to the EEC criteria for classification and labelling
requirements for dangerous substances (EEC Directive 83/467/EEC, Annex
VI of the EEC Council Directive 67/54B/EEC, DC5067 need not be labelled
as an eye irritant.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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