Registration Dossier
Registration Dossier
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The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
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EC number: - | CAS number: -
Eye irritation
Administrative data
- Endpoint:
- eye irritation, other
- Remarks:
- in vivo study
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2001
- Reliability:
- 1 (reliable without restriction)
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 001
- Report date:
- 2001
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 405 (Acute Eye Irritation / Corrosion)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Remarks:
- Bundesministerium für Land- und Forstwirtschaft Umwelt und Wasserwirtschaft, Vienna, Austria
Test material
- Reference substance name:
- -
- EC Number:
- 439-590-3
- EC Name:
- -
- Cas Number:
- 12158-75-7
- Molecular formula:
- Hill: Cu2(OH)3NO3 CAS:
- IUPAC Name:
- copper trihydroxynitrate
- Details on test material:
- CAS# 12158-75-7, Batch 060248
Constituent 1
Test animals / tissue source
- Species:
- rabbit
- Strain:
- New Zealand White
Test system
- Vehicle:
- water
- Controls:
- no
- Duration of treatment / exposure:
- 24 h
- Observation period (in vivo):
- 21 d
- Number of animals or in vitro replicates:
- 1 female
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- cornea opacity score
- Basis:
- animal #1
- Time point:
- other: 24-72 h
- Score:
- 2
- Max. score:
- 0
- Reversibility:
- not reversible
- Remarks on result:
- other: 21d: score: 3
- Irritation parameter:
- iris score
- Basis:
- animal #1
- Time point:
- other: 24-72 h
- Score:
- 1
- Max. score:
- 1
- Reversibility:
- fully reversible
- Remarks on result:
- other: 21 d score: 0
- Irritation parameter:
- other: conjunctivae redness
- Basis:
- animal #1
- Time point:
- other: 24-72 h
- Score:
- 2.7
- Max. score:
- 3
- Reversibility:
- fully reversible
- Remarks on result:
- other: 21d score: 0
- Irritation parameter:
- other: conjunctivae chemosis
- Basis:
- animal #1
- Time point:
- other: 24-72 h
- Score:
- 2.3
- Max. score:
- 4
- Reversibility:
- fully reversible
- Remarks on result:
- other: 21d score: 0
Applicant's summary and conclusion
- Interpretation of results:
- Category 1 (irreversible effects on the eye) based on GHS criteria
- Remarks:
- Migrated information
- Conclusions:
- the test substance causes irreversible ocular damages
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