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EC number: 701-292-9 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Endpoint summary
Administrative data
Description of key information
Key value for chemical safety assessment
Acute toxicity: via oral route
Link to relevant study records
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1990
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: see 'Remark'
- Remarks:
- GLP conform study following US regulation for the enforcement of the "Federal Hazardous Substances Act 16 CFR 1500". Reports are not as detailed as modern protocols but include all required information. The principles and methodology used for testing are comparable to modern OECD 423 guideline. As no relevant deficiencies have been detected, the study is considered to be reliable.
- Qualifier:
- according to guideline
- Guideline:
- other: US Regulation of the Federal Hazardous Substances Act (16 CFR 1500)
- Deviations:
- no
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 423 (Acute Oral toxicity - Acute Toxic Class Method)
- GLP compliance:
- yes
- Test type:
- acute toxic class method
- Limit test:
- yes
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Harlan Sprague-Dawley Inc.
- Age at study initiation: young
- Weight at study initiation: 211-258 g
- Fasting period before study: yes
- Housing: wire mesh suspension cages, 5 per cage
- Diet (e.g. ad libitum): purina laboratory chow
- Water (e.g. ad libitum): water ad libitum
- Acclimation period: min. 2 days
ENVIRONMENTAL CONDITIONS
- Photoperiod (hrs dark / hrs light): 12 hrs light/12 hrs dark - Route of administration:
- other: esophagel intubation
- Vehicle:
- corn oil
- Remarks:
- 25% (v/v)
- Doses:
- 5 g/kg body weight, calculated by using post-fasted body weights
- No. of animals per sex per dose:
- 5
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: Observation 2,5, 4,5 and 5 hours after dosing and once each day until end of the 14 day observation period. Body weights measured on the day of dosing and at the end of 14 day period.
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, body weight - Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 5 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- No deaths occured
- Clinical signs:
- other: other: No clinical signs observed
- Gross pathology:
- No observations in all rats
- Other findings:
- None
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- The results of the performed test on acute oral toxicity of hexagonal boron nitride to rats demonstrated that the LD50 is > 5000 mg/kg body weight. Hexagonal boron nitride is therefore not classified as hazardous.
- Executive summary:
Two groups, each of five male/female Sprague dawly rats, were treated with the test item by oral gavage administration at a dosage of 5000 mg/kg body weight. The test item was suspended in a vehicle (corn oil) at a concentration of 25% (v/v). All animals were allowed to acclimatise to the laboratory conditions for at least 2 days. The animals were observed for mortality/morbidity, clinical signs, body weights and examined macroscopically. All animals survived until the end of the 14-day observation period and no clinical signs were observed. At necropsy, no macroscopical findings were observed. Therefore, for hexagonal boron nitride the LD50 > 5000 mg/kg body weight and the substance should be not classified according to Annex I of Regulation (EC) 1272/2008.
Reference
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- LD50
- Value:
- > 5 000 mg/kg bw
Acute toxicity: via inhalation route
Link to relevant study records
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1990
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: see 'Remark'
- Remarks:
- GLP conform study not following any official guideline. The principles and methodology used for testing are comparable to modern OECD 42 guideline besides a lower frequency of observation of body weights which is not considered critical regarding reliability of the study. As no relevant deficiencies have been detected, the study is considered to be reliable.
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 403 (Acute Inhalation Toxicity)
- Deviations:
- yes
- Remarks:
- lower number of observations during observation period
- GLP compliance:
- yes
- Test type:
- standard acute method
- Limit test:
- no
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Charles River Laboratories, Portage, Michigan, USA
- Age at study initiation: 47-54 days
- Weight at study initiation: male 206-223 g, female 160-174 g
- Housing: individually in temperature and humidity-controlled rooms
- Diet (e.g. ad libitum): purina certified pelleted rodent chow #5002
- Water (e.g. ad libitum): tap water ad libitum
- Acclimatisation: 12 days
ENVIRONMENTAL CONDITIONS
- Photoperiod (hrs dark / hrs light): 12 hrs light/12 hrs dark - Route of administration:
- inhalation: aerosol
- Type of inhalation exposure:
- whole body
- Vehicle:
- air
- Details on inhalation exposure:
- GENERATION OF TEST ATMOSPHERE / CHAMBER DESCRIPTION
- Exposure apparatus: aerosol generation system (Test material was dispensed by a known and constant rate by an auger dust feed to an air-micrronizer (Fluid Energy, Model 0101). Dust was drawn into the micronizer by an aspirator, recirculated in the grinding chamberwhere particle-to-partivle impact reduced the size of the dust until the size was small enough to follow the air flow out of the micronizer. The resulting aerosole was piped to the exposure chamber.
- Exposure chamber volume: 54 L all glass exposure chamber
- Source and rate of air: in-house compressed-air system, flow rate 67 L/min
- Method of particle size determination: Andersen 8-stage cascade impactor. Mass median aerodynamic diameter (MMAD) and geometric standard deviation (GSD) were calculated similar to Raabe (Environ. Sci. Technol., 2:1162-1167, 1978)
- Temperature, humidity, pressure in air chamber: Temp.: 75-81°F, Rel. hum.: 49-60 %, Airflow: 67 L/min, Oxygen level: 19.9-20.1 %.
TEST ATMOSPHERE
- Brief description of analytical method used: Nominal exposure concentration calculated by dividing the amount of test material used by the total volume of air passed through the chamber. Actual exposure concentration was determined using a gravimetric method. Samples of aerosol atmosphere were collected on 25 mm glass-fiber filters, held in open face filter holders, positioned in the exposure chamber. Samples were drawn through the filters at 3 L/min for 2 minutes. Each filter was weighed prior to and again after sample collection. The concentration was calculated as the difference in filter weight, divided by the total sample volume. Four samples were collected during each exposure.
TEST ATMOSPHERE (if not tabulated)
- Particle size distribution: (Filter size and weight percent)
9 µm: 13.1 % (by weight)
5.8 µm: 27.8 % (by weight)
4.7 µm: 19.3 % (by weight)
3.3 µm: 24.5 % (by weight)
2.1 µm: 13.1 % (by weight)
1.05 µm: 1.9 % (by weight)
- MMAD (Mass median aerodynamic diameter) / GSD (Geometric st. dev.): Equivalent aerodynamic diameter: 5.3-8.4 µm GSD: 1.86-1.98
CLASS METHOD (if applicable)
- Rationale for the selection of the starting concentration: - Analytical verification of test atmosphere concentrations:
- yes
- Remarks:
- gravimetric
- Duration of exposure:
- 4 h
- Concentrations:
- 1.1 mg/L, 5.3 mg/L and 6.3 mg/L
- No. of animals per sex per dose:
- 5 male and 5 female per dose
- Control animals:
- not specified
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: Animal were observed immediately after exposure and twice daily after exposure. Body weights were recorded before exposure on day 7 and day 14.
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, body weight - Statistics:
- LC50 values were calculated similar to Bliss (C. I. Bliss, The Determination of the Dosage-Mortality Curve from Small Numbers, Quart. J. Pharm. Pharmacol. Vol. 11, 1938).
- Sex:
- male/female
- Dose descriptor:
- LC50
- Effect level:
- > 5.3 mg/L air (analytical)
- Based on:
- test mat.
- Exp. duration:
- 4 h
- Sex:
- male/female
- Dose descriptor:
- LC50
- Effect level:
- < 6.2 mg/L air (analytical)
- Based on:
- test mat.
- Exp. duration:
- 4 h
- Mortality:
- Five males and 2 females exposed to 6.2 mg/L and 1 male exposed to 5.3 mg/L died during the exposure due to suffocation from accumulated test material occulding the trachea.
- Clinical signs:
- other: Labored breathing was the most significant pharmacotoxic sign observed and was noted in most surviving animals.
- Body weight:
- Body weights were depressed in animals exposed to 5.3 mg/L but were normal in animals exposed to 1.1 mg/L.
- Gross pathology:
- The only exposure-related abnormality noted at necropsy were test material in the trachea and pulmonary congestion. These abnormalities were only observed in animal which died.
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- In summary, based on the data available from this study the 4 h LC50 value for hexagonal boron nitride was between 5.3 and 6.2 mg/L. It should be noted however, that the mechanism of death was due to a mechanical occulsion of the trachea from accumulated test material which resulted in suffocation. Performance of the study was comparable to modern OECD protocols and deficiencies relevant for reliability of the study have not been detected. Therefore, it is concluded that hexagonal boron nitride does not have to be classified as acute toxic by inhalation (LC50 > 5 mg/L).
Reference
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- LC50
- Value:
- > 5.3 - < 6.2 mg/L air
Acute toxicity: via dermal route
Link to relevant study records
- Endpoint:
- acute toxicity: dermal
- Data waiving:
- study scientifically not necessary / other information available
- Justification for data waiving:
- the study does not need to be conducted because the substance does not meet the criteria for classification as acute toxicity or STOT SE by the oral route and no systemic effects have been observed in in vivo studies with dermal exposure (e.g. skin irritation, skin sensitisation)
Reference
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
Justification for classification or non-classification
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