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EC number: 281-589-3
CAS number: 83969-12-4
The acute toxicity of Basic Blue 159 was investigated following dermal
administration of a single dose to the Sprague Dawley rat followed by a
14-day observation period. A single dose of 1000 mg/kg body weight was
administered to a group of 5 male and 5 female animals for 24 hours.
After 14 days, all animals were killed and subjected to necropsy to
examine macroscopic changes. No mortality occurred and no signs of
toxicity were observed in male or female animals during the observation
period. A second group of 5 male and 5 female animals was then dosed at
2000 mg/kg body weight for 24 hours, which were also necropsied after 14
days of observation. No mortality occurred and no signs of toxicity were
observed in male or female animals during the observation period. The
body weight changes observed during the study were within the expected
range for this species and age of animals. Only blue staining on the
treatment site, due to the colour of the substance, was found at
necropsy in all animals at termination of the study. These results
indicate that the test item, Basic Blue 159, has no toxic effect on the
rat following dermal exposure over a 24 hour period at a level of 2000
mg/kg body weight. The lack of mortality demonstrates the LD50 to be
greater than 2000 mg/kg body weight. European Directives concerning the
classification, packaging and labelling of dangerous substances (Council
Regulation (EC)No. 1272/2008 and subsequent revisions) would indicate
Classification No category
Signal word No signal word required
Hazard statement No hazard statement required
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