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EC number: 281-589-3
CAS number: 83969-12-4
An acute oral toxicity study was carried out with the test item in male
and female rats. Five rats/sex/dose groups received a single gavage of
the test item dissolved in distilled water at dose levels of 50, 100,
200, 250, 500, 800 mg/kg bw for males and 50, 100, 200, 250, 310 mg/kg
bw for females. The animals were observed for signs of toxicity for 14
Clinical signs observed in animals after a single administration of 100
to 800 mg/kg bw Basic Blue 159 were poor general condition,
piloerection, sedation and prone or lateral position. Occasionally,
tonic-clonic convulsions, laboured respiration and stilted gait
occurred. A slight delay in body weight development was observed in
females at a dose of 200 mg/kg bw in the first week of the study. In the
pathological-anatomical examination of the deceased male and female rats
at doses of 100 to 800 mg/kg bw, non-specific damage to the
gastrointestinal tract and in part reddening of the lungs were observed.
A dose of 50 mg/kg was tolerated without any clinical signs.
The following deaths were observed during the post-treatment phase:
Dose [mg/kg bw]
No of deaths
Time of death
Mortality rate [%]
The resulting oral LD50 for males and females together was calculated to
be 216 mg/kg bw (CI 172 to 272 mg/kg bw) based on test material. This
calculated to 124 mg/kg bw for the active ingredient.
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