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EC number: 407-240-9
CAS number: 159604-94-1
BLUE 10 25 964
The purpose of this study was to assess the toxicity of the test article when administered to rats as a single oral dose.
The study was carried out in accordance with OECD Guideline No. 401, "Acute Oral Toxicity n and EEC Directive 84/449/EEC, Part B. 1, "Acute Toxicity-oral ". The test item was administered by oral gavage, to five rats of each sex, at 5000 mg/kg body weight. Macroscopic examination was performed at the end of the experimental period.
Three animals died within 24 hours of dosing.
Lethargy, piloerection and convulsions were noted among the animals on the day of treatment.
All animals showed body weight gain over the study period.
Macroscopic post mortem examination of the animals that died during the study revealed the stomach and intestine contents to be blue (test substance) . Macroscopic post mortem examination of the surviving animals at termination revealed the lungs of one male to be flecked grey/green and the urinary bladders of two males to contain white particles.
The oral LD50 value of the test item in rats of either sex was established as exceeding 5000 mg/kg body weight.
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