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EC number: 248-607-1
CAS number: 27689-12-9
dermal sensitization potential of a saline extract of the test article
(liquid, lot number not reported) was evaluated in the Freund’s Complete
Adjuvant Test using guinea pigs (sex not reported). This study was not
performed under GLP guidelines. The study design was based on OECD 406
(1981) and EEC Guidelines, B.6 (1984). This study design is similar to
the Guinea Pig Maximization Test. The test article was diluted in
vehicle (exact vehicle not listed) prior to administration. Five guinea
pigs received intradermal injections on the flanks with 0.1 mL of a 5%
dilution of the test article in vehicle with the same volume of Freund’s
Complete Adjuvant (FCA) on Days 1, 5, and 9. Five control animals
received pretreatment with 0.05 mL of FCA only. On Day 22, all animals
received 0.025 mL of 10, 30 or 100% test article as a topical
application on one 2 cm2 site per treatment per animal. Skin reactions
were read at 24, 48, and 72 hours after application of the test
material. No erythema was observed at up to 100% test article on any
animals at any time following the challenge treatment. Based on the
results of this study, the test article presented no evidence of a
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