Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 248-607-1
CAS number: 27689-12-9
primary skin irritation potential of the test article (liquid, batch
P2274001) was evaluated in New Zealand White rabbits. This study was
conducted in accordance with Swiss GLP (1986), OECD GLP (1992), US FDA
GLP 21CFR58, Japan MHLW (1988). The study design was based on Directive
92/69/EEC, B.4 (1992) and OECD 404 (1993). The test article was
administered as received. Hair was clipped from the dorsal skin of three
rabbits (1 male, 2 females). The test article (0.5 mL) was applied to a
6 cm2 area on the skin. Gauze was used to cover the site and create a
semi-occlusive dressing. The dressing was secured around the abdomen
with tape for a 4-hour exposure. Observations for skin irritation
(erythema and edema) were recorded at 1, 24, 48 and 72 hours after
unwrapping. The Primary Irritation Index (PII) was calculated. There
were no abnormal clinical signs or changes in body weight. All erythema
and edema scores were 0 throughout the study and the PII was 0. Based on
the results of this study (all scores were 0; PII = 0), the test article
is not a dermal irritant.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
Welcome to the ECHA website. This site is not fully supported in Internet Explorer 7 (and earlier versions). Please upgrade your Internet Explorer to a newer version.
Do not show this message again