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EC number: 248-607-1
CAS number: 27689-12-9
A Primary Skin Irritation study and an Eye Irritation study have been conducted on Procrylat. The substance was non-irritating to the eyes and non-irritating to the skin.
A Primary Skin Irritation
study and an Eye Irritation study have been conducted on Procrylat. The
substance was non-irritating to the eyes and non-irritating to the skin.
eye irritation/corrosion potential of the test article (liquid, batch
P2274001) was evaluated in New Zealand White Rabbits. This study was
performed in accordance with Swiss GLP (1986), OECD GLP (1992), US FDA
GLP 21CFR58, Japan MHLW (1988). The study design was based on Directive
92/69/EEC, B.5 (1992) and OECD 405 (1987). The test material (0.1 mL)
was administered as received to the conjunctival sac of one eye of each
rabbit (1 male, 2 females) by gently pulling the lower eyelid away from
the eye. The lids were held together for approximately one second after
administration to insure adequate distribution of the test material. The
contralateral eye of each animal served as the control. The treated eye
of each rabbit was examined for irritation of the cornea, iris and
conjunctiva at 1, 24, 48 and 72 hours postdose using the Draize
technique. There were no systemic clinical signs, corneal opacity,
iritis or conjunctival chemosis at any time during the study.
Conjunctival redness was observed in all animals at 1 hour after dosing
(score: 1, one animal and 2, two animals; average: 1.67) that persisted
through 48 hours after dosing (scores: 1; average 1.00). All animals
were normal at 72 hours after dosing. The individual animal mean
conjuctival redness scores (24 -72 hours) were 0.67, 0.67, and 0.67. The
mean total score for ocular irritation was 0.67/110. Based on the
results of the study, the test article is not an ocular irritant.
skin irritation potential of the test article (liquid, batch P2274001)
was evaluated in New Zealand White rabbits. This study was conducted in
accordance with Swiss GLP (1986), OECD GLP (1992), US FDA GLP 21CFR58,
Japan MHLW (1988). The study design was based on Directive 92/69/EEC,
B.4 (1992) and OECD 404 (1993). The test article was administered as
received. Hair was clipped from the dorsal skin of three rabbits (1
male, 2 females). The test article (0.5 mL) was applied to a 6 cm2 area
on the skin. Gauze was used to cover the site and create a
semi-occlusive dressing. The dressing was secured around the abdomen
with tape for a 4-hour exposure. Observations for skin irritation
(erythema and edema) were recorded at 1, 24, 48 and 72 hours after
unwrapping. The Primary Irritation Index (PII) was calculated. There
were no abnormal clinical signs or changes in body weight. All erythema
and edema scores were 0 throughout the study and the PII was 0. Based on
the results of this study (all scores were 0; PII = 0), the test article
is not a dermal irritant.
not meet the CLP classification criteria for eye or skin irritation.
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