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EC number: 203-710-0
CAS number: 109-83-1
The application of the test substance caused
systemic toxicity, including mortality, in a dose dependent manner.
In an acute oral study a test group
consisting of 5 animals/sex was treated by single gavage application
with an aqueous solution of MMEA (BASF AG, 1965, XV/126). The animals
were observed for mortality and for clinical symptoms of toxicity. At
the end of the observation period of 14 days, the surviving animals were
sacrificed for the purpose of necropsy; animals that died during the
observations period also were subjected to necropsy. The LD50 value was
estimated on the basis of the observed mortalities.
At low doses (23.5 188 and 752 mg/kg bw),
calm behavior was observed by treated animals. Dyspnoea, chewing
compulsion, partially calm behavior occurred after application of 1504
mg/kg bw. After 24 h, crusted eyes and ruffled fur.
At high doses (1880, 2350 and 3008 mg/kg
bw), dyspnoea, high stepping gait, staggering, smeared fur, diarrhea,
calm behavior, chewing compulsions and gasping were observed. After 24 h
squatting posture, ruffled fur, irregular accelerated respiration and
abdominal position were still present. At 1880 mg/kg bw: 1 animal had
distended ulceration with phlegmone and abscess of the entire glandular
stomach and intestinal irritation. At the highest dose, intestinal atony
was observed in one animal.
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