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EC number: 214-275-1
CAS number: 1119-34-2
Absorption to solid phase is not expected.
In accordance with REACH Annex VIII section 9.3.1. column 2 as well as
REACH Annex IX section 9.3.3. column 2 the study on
adsorption/desorption screening (required in section 9.3.1. column 1)
does not need to be conducted as the substance has a low log Kow as well
as the substance and its degradation products decompose rapidly.
Adsorption to solid soil phase is not expected. From the water surface
L-arginine-HCl will not evaporate into the atmosphere.
Despite of that Koc was estimated by calculation by EpiSuite's KOCWIN
model. Read-across was performed from L-arginine to L-arginine-HCl.
L-arginine-HCl as such is not a natural constituent of peptides
and proteins. L-arginine-HCL is the salt resulting from the reaction of
the basic L-arginine with HCl. Due to is higher water solubility
L-arginine-HCl is often preferably applied than L-arginine, in
particular when bioavailability is desired property for the intended use.
L-arginine-HCl dissociates in aqueous solution to ionic L-arginine
as well as H+and Cl-. The inorganic ions resulting
from physiological concentrations are not of concern for toxicokinetics
as the “background” concentration in the body is by magnitudes higher.
EpiSuite's KOCWIN model is not applicable for L-arginine-HCL as the
model attributes the substance to a wrong chemical substance class.
Consequently, the Koc estimate would be outside the program's prediction
The suitability of the model was assessed for L-arginine and it was
concluded that L-arginine is considered to be inside the applicability
domain of the EpiSuite KOCWIN model.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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