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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Acute Toxicity: inhalation

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Administrative data

Endpoint:
acute toxicity: inhalation
Type of information:
migrated information: read-across from supporting substance (structural analogue or surrogate)
Adequacy of study:
weight of evidence
Study period:
1971
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Older study conducted prior to the introduction of GLP and OECD test guidelines. Standard methods used but details of methods and results not available. For read-across justification see Section 13.

Data source

Reference
Reference Type:
other company data
Title:
Unnamed
Year:
1971
Report date:
1971

Materials and methods

Test guideline
Qualifier:
no guideline followed
Principles of method if other than guideline:
Rats given single doses of DUP of up to at least 1.8 mg/l as a vapour. Animals observed for signs of toxicity for 10 days. Animals weighed and subject to necropsy and macroscopic examination.
GLP compliance:
no
Test type:
standard acute method
Limit test:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
Diundecyl phthalate, branched and linear
EC Number:
287-401-6
EC Name:
Diundecyl phthalate, branched and linear
Cas Number:
85507-79-5
Molecular formula:
C30H50O4
IUPAC Name:
diundecyl phthalate
Details on test material:
- Molecular formula (if other than submission substance): C30 H50 O4
- Molecular weight (if other than submission substance): 474.73
- Smiles notation (if other than submission substance): O=C(OCCCCCCCCCCC)c(c(ccc1)C(=O)OCCCCCCCCCCC)c1

Test animals

Species:
rat
Strain:
not specified
Sex:
not specified
Details on test animals or test system and environmental conditions:
No data

Administration / exposure

Route of administration:
inhalation: vapour
Type of inhalation exposure:
not specified
Vehicle:
not specified
Details on inhalation exposure:
6 h exposure at room temperature & 300 degrees F
Analytical verification of test atmosphere concentrations:
not specified
Duration of exposure:
6 h
Concentrations:
Up to at least 1.8 mg/l
No. of animals per sex per dose:
4
Control animals:
not specified
Details on study design:
- Duration of observation period following administration: 14 days (or other?): 10d
- Frequency of observations and weighing: no data
- Necropsy of survivors performed: yes/no: yes
- Other examinations performed: clinical signs, body weight, organ weights, histopathology, other: No
Statistics:
No data

Results and discussion

Effect levelsopen allclose all
Sex:
not specified
Dose descriptor:
LC50
Effect level:
> 1.8 mg/L air (nominal)
Based on:
test mat.
Exp. duration:
6 h
Remarks on result:
other: Room temperature; No 95% confidence limits calculable
Sex:
not specified
Dose descriptor:
LC50
Effect level:
> 1.8 mg/L air (nominal)
Based on:
test mat.
Exp. duration:
6 h
Remarks on result:
other: T degrees F = 300; 95% CL not calculable
Mortality:
None at room temperature or 300 degrees F
Clinical signs:
other: No toxic effects at room temperature. At 300 degrees F slight lethargy
Body weight:
None at room temperature or 300 degrees F
Gross pathology:
None at room temperature or 300 degrees F

Applicant's summary and conclusion

Interpretation of results:
relatively harmless
Remarks:
Migrated information Criteria used for interpretation of results: expert judgment
Conclusions:
Six hours exposure to a saturated vapour concentration of 1.8 mg/L, resulted in no mortality.
Executive summary:

Six hours exposure to a saturated vapour concentration of 1.8 mg/L, resulted in no mortality. The vapour concentration tested is considered to represent the highest achievable