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EC number: 271-085-1
CAS number: 68515-43-5
NOEC - 0.32 mg/L
The phthalate esters are1,2-benzenedicarboxylic acids with side chain
esters ranging in carbon chain length from C1 to C13.The US EPA High
Production Volume (HPV) chemical challenge program has proposed grouping
phthalate esters into a single category, divided into 3 sub-categories,
this based on the structural similarities of the substances and their
physicochemical and toxicological properties. These sub-categories are:
low molecular weight phthalates, transitional phthalates, and high
molecular weight phthalates. The high molecular weight phthalates are
defined as being produced from alcohols with straight-chain carbon
backbones of >C7 or a ring structure. These include varying mixed
isomers of linear and branched diheptyl, dioctyl, dinonyl, didecyl,
diundecyl and ditridecyl phthalate. All exhibit low solublity in water
and are regarded as being too insoluble to exhibit acute or chronic
toxicity. Read-across from closely related phthalates thus appears
reasonable and this is supported by the data, below:
Acute toxicity to fish (Salmo gairdneri) of the substance (chain length
C9 -C11) has been investigated over a 96 hour exposure period with fish
exposed to the substance at the limits of solubility in the test medium.
No toxicity was observed. No toxicity was observed in a second test in
the same species with fish exposed to the substance at a concentration
in excess of the water solubility.
Acute toxicity to fish (Salmo gairdneri) of a phthalate ester with C11
chain length has been investigated over a 96 hour exposure period. The
LC50 was in excess of 1.4 mg/L, the highest concentration examined which
was at or in excess of the water solubility of the substance. Acute
toxicity to another freshwater species, fathead minnow, has been
determined over a 96 hour period. The LC50 was in excess of 1.3 mg/L,
the highest concentration examined which was at or in excess of the
water solubility of the substance. Testing in another freshwater
species, bluegill, resulted in a LC50 in excess of 0.73 mg/L, the
highest concentration examined. Acute toxicity to a marine species,
sheepshead minnow, has been determined. The 96 hour LC50 was in excess
of 0.22 mg/L, the highest concentration investigated which was at or in
excess of the water solubility of the substance.
Acute toxicity to fish (Brachydanio rerio) of a phthalate ester with C8
-C10 chain length has been investigated over a 96 hour exposure period
with fish exposed to the substance in a water accommodated fraction
(measured concentration 0.32 mg/L). No toxicity was observed.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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