Sodium dimethyl 5-sulphonatoisophthalate

Acute Toxicity: inhalation

Administrative data

Endpoint:

acute toxicity: inhalation

Type of information:

experimental study

Adequacy of study:

key study

Study period:

1959

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: Scientifically valid study without detailed documentation

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1959

Report date:

1959

Materials and methods

Test guideline

Qualifier:

no guideline followed

Principles of method if other than guideline:

Study predates OECD guidelines. However, it follows the principles of a OECD guideline 403 limit test.

GLP compliance:

no

Remarks:

Study performed prior to implementation of GLP

Test type:

standard acute method

Limit test:

yes

Test material

Test material information

Constituent 1

Reference substance name:

Sodium dimethyl 5-sulphonatoisophthalate

EC Number:

223-578-8

EC Name:

Sodium dimethyl 5-sulphonatoisophthalate

Cas Number:

3965-55-7

Molecular formula:

C10H10O7S.Na

IUPAC Name:

sodium 3,5-bis(methoxycarbonyl)benzenesulfonate

Test material form:

other: solid

Test animals

Species:

rat

Strain:

other: ChR-CD

Administration / exposure

Route of administration:

inhalation: dust

Type of inhalation exposure:

not specified

Details on inhalation exposure:

> 75 % of particles were < 3µm in diam.

Analytical verification of test atmosphere concentrations:

yes

Duration of exposure:

4 h

Concentrations:

32 mg/lit +/- 20 %

No. of animals per sex per dose:

2 animals per dose

Details on study design:

- Observation period: at least 9 days
- Necropsy of survivors performed: yes

Results and discussion

Effect levels

Sex:

not specified

Dose descriptor:

LC0

Effect level:

>= 32 mg/L air

Based on:

test mat.

Exp. duration:

4 h

Mortality:

no mortality

Clinical signs:

other: Discomfort during exposure

Body weight:

no data

Gross pathology:

None of the pathological changes attributable to treatment found 9 days after exposure

Applicant's summary and conclusion

Conclusions:

Under the conditions of the present study the approximate lethal concentration is > 32 mg/L.

Executive summary:

In an acute inhalation toxicity study ( Haskell Laboratory for Toxicology and Industrial Medicine, 1959, non-GLP) two rats were treated with Sodium Sulfo Dimethylisophtalate dust in concentrations of 32 mg/L +/- 20 % for 4 hours by inhalation. More than 75 % of the dusts particles had a size < 3µm in diameter. As clinical signs discomfort during exposure were noted. Mortality did not occur within the 9 -day observation period. At nercopsy none of the pathological changes were attributable to treatment. The results of the study indicate a LC0 of > 32 mg/L.