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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
key study
Study period:
1959
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Scinetifically valid study without detailed documentation

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1959
Report date:
1959

Materials and methods

Test guideline
Qualifier:
no guideline followed
Principles of method if other than guideline:
In this study predating the implementation of OECD guidelines seven dose levels were tested. One rat per dose was used, the observation time was 10-12 days. Clinical signs were examined, macroscopical examination at necropsy was performed.
GLP compliance:
no
Remarks:
study performed prior to implementation of GLP
Test type:
standard acute method
Limit test:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
Sodium dimethyl 5-sulphonatoisophthalate
EC Number:
223-578-8
EC Name:
Sodium dimethyl 5-sulphonatoisophthalate
Cas Number:
3965-55-7
Molecular formula:
C10H10O7S.Na
IUPAC Name:
sodium 3,5-bis(methoxycarbonyl)benzenesulfonate
Test material form:
not specified
Details on test material:
substance name used in report: Sodium Sulfo Dimethylisophthalate

Test animals

Species:
rat
Strain:
other: ChR-CD
Sex:
not specified

Administration / exposure

Route of administration:
oral: gavage
Vehicle:
other: 30% susp. in 1% aqueous gum guar
Doses:
1000, 1500, 2250, 3400, 5000, 7500 and 11000 mg/kg bw.
Doses from 1000 to 5000 mg/kg bw were given as a single dose, whereas 7500 and 11000 mg/kg bw were given as 2 doses within 1 hr.
No. of animals per sex per dose:
1 animal per dose
Control animals:
no
Details on study design:
- Duration of observation period following administration: 10-12 days
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs

Results and discussion

Effect levels
Sex:
not specified
Dose descriptor:
LD0
Effect level:
11 000 mg/kg bw
Based on:
test mat.
Mortality:
no mortality
Clinical signs:
other: Diarrhea, white precipitate in urine and feces, discomfort, weight loss in some cases. Minimal effects at 3400 mg/kg bw and less.
Gross pathology:
None attributable to treatment found 10-12 days after exposure.

Applicant's summary and conclusion

Conclusions:
Under the conditions of the present study the approximate lethal dose (LDLo) was > 11000 mg/kg.
Executive summary:

In an acute oral toxicity study (Haskell Laboratory for Toxicology and Industrial Medicine, 1959, non-GLP) rats (1/dose) were treated orally with Sodium Sulfo Dimethylisophtalate in concentrations of 7500, 5000, 3400, 2250, 1500 and 1000 mg/kg by a single dose. Furthermore, 11000 and 7500 mg/kg were given in 2 doses within one hour. Diarrhea, white precipitate in urine and feces, discomfort, wt. loss in some cases were observed. Effects were minimal at 3400 mg/kg and less. No mortility occurred leading to an approximate lethal dose (LDLo) of > 11000 mg/kg.