Iron(1+), chloro[dimethyl 9,9-dihydroxy-3-methyl-2,4-di(2-pyridinyl-kN)-7-[(2-pyridinyl-kN)methyl]-3,7-diazabicyclo[3.3.1]nonane-1,5-dicarboxylate-kN3,kN7]-, chloride

Particle size distribution (Granulometry)

Administrative data

Endpoint:

particle size distribution (granulometry)

Type of information:

experimental study

Adequacy of study:

key study

Study period:

June 2017

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

comparable to guideline study

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

2017

Report date:

2017

Materials and methods

Test guideline

Test guideline 1

Qualifier:

equivalent or similar to guideline

Guideline:

ISO 13320 (Particle size analysis - Laser diffraction methods)

Test guideline 2

Qualifier:

equivalent or similar to guideline

Guideline:

OECD Guideline 110 (Particle Size Distribution / Fibre Length and Diameter Distributions - Method A: Particle Size Distribution (effective hydrodynamic radius)

Principles of method if other than guideline:

Laser diffraction is used for determination of particle size distribution. The sample is dispersed in air or liquid. The laser passes through the dispersion media and is diffracted by the particles. The image of diffraction produced by the particles is measured, and particle size distribution is calculated using Mie theory of light scattering.

GLP compliance:

no

Other quality assurance:

other: Plant Certification ISO9001/ISO14001/ISO50001/OHSAS18001

Type of method:

Laser scattering/diffraction

Type of particle tested:

other: powder

Type of distribution:

volumetric distribution

Test material

Test material information

Constituent 1

Reference substance name:

1,5-dimethyl 3-methyl-9-oxo-2,4-bis(pyridin-2-yl)-7-[(pyridin-2-yl)methyl]-3,7-diazabicyclo[3.3.1]nonane-1,5-dicarboxylate dichloroiron hydrate

EC Number:

610-388-9

Cas Number:

478945-46-9

Molecular formula:

C28H31N5O6FeCl2

IUPAC Name:

1,5-dimethyl 3-methyl-9-oxo-2,4-bis(pyridin-2-yl)-7-[(pyridin-2-yl)methyl]-3,7-diazabicyclo[3.3.1]nonane-1,5-dicarboxylate dichloroiron hydrate

Test material form:

solid: particulate/powder

Results and discussion

Particle size

Particle size 1

Key result

Percentile:

D10

Mean:

1 µm

Remarks on result:

other: volume median diameter

Particle size 2

Key result

Percentile:

D50

Mean:

60 µm

Remarks on result:

other: volume median diameter

Particle size 3

Key result

Percentile:

D90

Mean:

478 µm

Remarks on result:

other: volume median diameter

Any other information on results incl. tables

Particle size distribution:

Particle Size  Volume (%)  0 to 5μm  29%  5 to 10 µm  8%  10 to 100 µm  21%  > 100 µm  42%

 

Applicant's summary and conclusion

Conclusions:

D(10): 1 µm; is the diameter where 10% of the volume distribution is below.
D(50): 60 µm; The volume median diameter is the diameter where 50% of the distribution is above and 50% is below.
D(90): 478 µm; is the diameter where 90% of the volume distribution is above.
Particle size distribution: 0-5 µm: 29%, 5-10 µm: 8%, 10-100 µm: 21%, >100 µm: 42% (% volume)

Executive summary:

The test item was assessed for particle size distribution by laser diffraction method. A Malvern apparatus was used, the sample was dispersed in air. The image of diffraction produced by the particles was measured, and particle size distribution was calculated using Mie theory of light scattering. The results are:

D(10): 1 µm; is the diameter where 10% of the volume distribution is below.

D(50): 60 µm; The volume median diameter is the diameter where 50% of the distribution is above and 50% is below.

D(90): 478 µm; is the diameter where 90% of the volume distribution is above.

Particle size distribution: 0-5 µm: 29%, 5-10 µm: 8%, 10-100 µm: 21%, >100 µm: 42% (% volume)