Iron(1+), chloro[dimethyl 9,9-dihydroxy-3-methyl-2,4-di(2-pyridinyl-kN)-7-[(2-pyridinyl-kN)methyl]-3,7-diazabicyclo[3.3.1]nonane-1,5-dicarboxylate-kN3,kN7]-, chloride

Surface tension

Administrative data

Endpoint:

surface tension

Type of information:

experimental study

Adequacy of study:

key study

Study period:

From 2004-04-21 to 2004-06-23

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

2004

Report date:

2004

Materials and methods

Test guideline

Test guideline 1

Qualifier:

according to guideline

Guideline:

EU Method A.5 (Surface Tension)

Deviations:

no

Test guideline 2

Qualifier:

according to guideline

Guideline:

other: ISO 304 ring method

Deviations:

yes

Remarks:

The resut was not corrected using Harkins-Jordan correction table as the correction is not applicable to the apparatus used. Once calibrated, the balance and ring assembly used give a direct reading for surface tension that is within the required accuracy

GLP compliance:

yes (incl. QA statement)

Type of method:

ring method

Test material

Test material information

Constituent 1

Reference substance name:

1,5-dimethyl 3-methyl-9-oxo-2,4-bis(pyridin-2-yl)-7-[(pyridin-2-yl)methyl]-3,7-diazabicyclo[3.3.1]nonane-1,5-dicarboxylate dichloroiron hydrate

EC Number:

610-388-9

Cas Number:

478945-46-9

Molecular formula:

C28H31N5O6FeCl2

IUPAC Name:

1,5-dimethyl 3-methyl-9-oxo-2,4-bis(pyridin-2-yl)-7-[(pyridin-2-yl)methyl]-3,7-diazabicyclo[3.3.1]nonane-1,5-dicarboxylate dichloroiron hydrate

Test material form:

solid: particulate/powder

Specific details on test material used for the study:

SOURCE OF TEST MATERIAL
- Source and lot/batch No.of test material: S2539801
- Expiration date of the lot/batch:
- Purity test date: 2004-11-12

RADIOLABELLING INFORMATION (if applicable) no

STABILITY AND STORAGE CONDITIONS OF TEST MATERIAL
ambient/dark

TREATMENT OF TEST MATERIAL PRIOR TO TESTING: no

Results and discussion

Surface tension

Key result

Surface tension:

70.7 mN/m

Temp.:

19.5 °C

Conc.:

1 g/L

Any other information on results incl. tables

The readings, times and temperatures for the sample solution ar shown in the following table:

Time (min)  Reading (mN/m)  Temperature (°C)  67  70.0  19.4  79  70.5  19.6  86  70.5  19.6  93  70.5  19.6  101  70.5  19.8  113  70.5  19.8

Mean (of last five readings)=70.5 mN/m

Surface tension=reading*calibratiopn factor=70.5*1.003=70.7 mN/m

Temperature=19.5 +/-0.5°C

pH of sample solution=4.4

Based on the pH of the sample solution and information obtained in the hydrolysis study, it was considered that negligible hydrolysis of the sample solution occurred during the course of the surface tension test.

Applicant's summary and conclusion

Conclusions:

The surface tension of a 1.00 g/L solution of test material has been determined to be 70.7 mN/m at 19.5+/-0.5°C. The test material is considered not to be a surface-active material.

Executive summary:

The purpose of the study was to determine the surface tension of the test material according to A5 method and following GLP. The platinum ring method was used. The surface tension of a 1.00 g/L solution of test material has been determined to be 70.7 mN/m at 19.5+/-0.5°C. The test material is considered not to be a surface-active material.