Alcohols, C16-18

Acute Toxicity: dermal

Administrative data

Endpoint:

acute toxicity: dermal

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

study well documented, meets generally accepted scientific principles, acceptable for assessment

Data source

Reference

Reference Type:

publication

Title:

ALFOL 1618 alcohol.

Author:

Continental Oil Company,Hayes Consultancy Service Bromley, Kent

Year:

1979

Bibliographic source:

Toxicity test summary dated February 8th 1979.

Materials and methods

Test guideline

Qualifier:

no guideline followed

Principles of method if other than guideline:

Method other: screening test
One rabbit was exposed at each of 5 dose levels ranging from 1 to 10 g/kg. The treated area was covered with a plastic shield for an exposure period of 24 hours. The animals were then observed for 14 days.

GLP compliance:

not specified

Test type:

other: screening test

Limit test:

no

Test material

Test material information

Constituent 1

Reference substance name:

Alcohols, C16-18

EC Number:

267-008-6

EC Name:

Alcohols, C16-18

Cas Number:

67762-27-0

Molecular formula:

C16 H34 O

IUPAC Name:

Alcohols, C16-18

Details on test material:

- Name of test material (as cited in study report):Tradename Alfol 1618 C16-18 alcohols 100% linear

Test animals

Species:

rabbit

Strain:

New Zealand White

Sex:

not specified

Details on test animals or test system and environmental conditions:

TEST ORGANISMS: Rabbit (New Zealand White)
- Source: Not reported.
- Weight at study initiation: 2.3-3 kg
- Group size: 5 (sex unspecified

Administration / exposure

Type of coverage:

occlusive

Vehicle:

other: undiluted (heated to melting point)

Details on dermal exposure:

ADMINISTRATION: 24 hour occluded exposure
- Area covered: trunk of animal
- Occlusion: plastic sleeve
- Vehicle: undiluted (heated to melting point)
- Doses: 1, 2.5, 5, 7.5 and 10 g/kg
- Removal of test substance: not reported

EXAMINATIONS: Mortality, behaviour and weight gain were observed over the 14 day observation period.

Duration of exposure:

24 hour occluded exposure

Doses:

1, 2.5, 5, 7.5 and 10 g/kg

No. of animals per sex per dose:

5

Control animals:

no

Details on study design:

EXAMINATIONS: Mortality, behaviour and weight gain were observed over the 14 day observation period.
One rabbit was exposed at each of 5 dose levels ranging from 1 to 10 g/kg. The treated area was covered with a plastic shield for an exposure period of 24 hours. The animals were then observed for 14 days.

Results and discussion

Effect levels

Sex:

not specified

Dose descriptor:

LD50

Effect level:

> 10 000 mg/kg bw

Based on:

test mat.

Mortality:

All animals survived the exposure and observation period.

Clinical signs:

other: None reported.

Gross pathology:

Not carried out.

Other findings:

POTENTIAL TARGET ORGANS: None identified
SEX-SPECIFIC DIFFERENCES: Sex not specified.

Applicant's summary and conclusion

Interpretation of results:

other: not classified

Remarks:

Criteria used for interpretation of results: EU

Conclusions:

The rabbit dermal LD50 (24 hour occluded) for Alcohols, C16-18 was >10000 mg/kg . There were no deaths or reports of toxicity.

Executive summary:

All 5 animals survived. The LD50 was found to be greater than 10,000 mg/kg bw.