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REACH

Alcohols, C16-18

EC number: 267-008-6 | CAS number: 67762-27-0 This substance is identified by SDA Substance Name: C16-C18 alkyl alcohol and SDA Reporting Number: 19-060-00.

Life Cycle description
Uses advised against

Ecotoxicological information

Toxicity to aquatic plants other than algae

Currently viewing:

Administrative data

Link to relevant study record(s)

Reference

Endpoint:

toxicity to aquatic plants other than algae

Type of information:

(Q)SAR

Adequacy of study:

weight of evidence

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

results derived from a valid (Q)SAR model and falling into its applicability domain, with adequate and reliable documentation / justification

Justification for type of information:

QSAR prediction: US EPA accepted QSAR method for organic chemicals properties assessment.

Qualifier:

according to guideline

Guideline:

other: QSAR

Principles of method if other than guideline:

ECOSAR Program(v1.00)

GLP compliance:

Remarks:

not applicable to QSAR models

Analytical monitoring:

Vehicle:

Test organisms (species):

other: QSAR model

Test type:

other: QSAR model

Water media type:

freshwater

Limit test:

Total exposure duration:

30 d

Hardness:

not applicable. QSAR model

Test temperature:

not applicable. QSAR model

pH:

not applicable. QSAR model

Dissolved oxygen:

not applicable. QSAR model

Salinity:

not applicable. QSAR model

Details on test conditions:

CAS Number: 67762-27-0
SMILES : CCCCCCCCCCCCCCCCO
CHEM : Alcohols, C16-18
MOL FOR: C16 H34 O1
MOL WT : 242.45
Log Kow: 6.73 (KowWin estimate)
Wat Sol: 0.0412 mg/L (experimental database)

Reference substance (positive control):

Duration:

96 h

Dose descriptor:

EC50

Effect conc.:

0.054 mg/L

Nominal / measured:

nominal

Conc. based on:

test mat.

Basis for effect:

other: (Q)SAR prediction

Remarks on result:

other: non-toxic at the limit of solubility, as determined by (Q)SAR

Duration:

96 h

Dose descriptor:

EC50

Effect conc.:

540 mg/L

Nominal / measured:

nominal

Conc. based on:

test mat.

Basis for effect:

other: (Q)SAR prediction

Remarks on result:

other: Predicted, at water solubility loading rates of 1000 mg/L

Duration:

30 d

Dose descriptor:

NOEC

Effect conc.:

0.045 mg/L

Nominal / measured:

nominal

Conc. based on:

test mat.

Basis for effect:

other: (Q)SAR prediction

Remarks on result:

other: non-toxic at the limit of solubility, as determined by (Q)SAR

Duration:

30 d

Dose descriptor:

NOEC

Effect conc.:

450 mg/L

Nominal / measured:

nominal

Conc. based on:

test mat.

Basis for effect:

other: (Q)SAR prediction

Remarks on result:

other: Predicted, at water solubility loading rates of 1000 mg/L

Details on results:

A 96 h LC50 value of 0.054 mg/L has been calculated for the effects of the test substance on the mortality of the Green Algae and Aquatic plants. This result signifies that the test substance is not expected to be toxic at the limit of solubility. This result is above the LoS (limit of solubility), therefore the substance is non-toxic at the limit of LoS and LC50 is >LoS.
A reliable 96 h LC50 value of 540 mg/L has been calculated for the effects of the test substance towards Green Algae and Aquatic plants. Therefore the test substance has been predicted to be non toxic at the limit of solubility, so the LC50 is 0.054 mg/L. Predicted to be non-toxic at the limit of solubility.

A NOEC value of 0.045 mg/L has been calculated for the effects of the test substance on the mortality of the Green Algae and Aquatic plants. This result signifies that the test substance is not expected to be toxic at the limit of solubility. This result is above the LoS (limit of solubility), therefore the substance is non-toxic at the limit of LoS and NOEC is >LoS.
A reliable NOEC value of 450 mg/L has been calculated for the effects of the test substance towards Green Algae and Aquatic plants. Therefore the test substance has been predicted to be non toxic at the limit of solubility, so the NOEC is 0.045 mg/L. Predicted to be non-toxic at the limit of solubility.
The water solubility of the Alcohols, C16-18 is 0.0412 mg/l at 25 degC (experimental database). This is about 10000 times the water solubility of the test substance.

Overview of QSARs estimations on aquatic toxicity of

Alcohols, C16-18

to algae and aquatic plants

Method

Results

Remarks

Reference

QSAR

estimate

Green Algae and Aquatic plants,96-hr EC50 = 0.054 mg/L (ppm)

Green Algae and Aquatic plants, 30-day, ChV (chronic value) =0.045 mg/L(ppm)

Reliable withrestrictions,

QSAR estimated data

ECOSAR Program (v1.00)

Green Algae and Aquatic plants,96-hrEC50 =0.054 mg/L (ppm)

Green Algae and Aquatic plants, 30-day, ChV (chronic value) =0.045 mg/L(ppm)

Validity criteria fulfilled:

yes

Remarks:

US EPA accepted QSAR method for organic chemicals properties assessment.

Conclusions:

Executive summary:

A reliable 96 h LC50 value of 540 mg/L has been calculated for the effects of the test substance towards Green Algae and Aquatic plants. Therefore the test substance has been predicted to be non toxic at the limit of solubility, so the LC50 is 0.054 mg/L. Predicted to be non-toxic at the limit of solubility.

A NOEC value of 0.045 mg/L has been calculated for the effects of the test substance on the mortality of the Green Algae and Aquatic plants. This result signifies that the test substance is not expected to be toxic at the limit of solubility. This result is above the LoS (limit of solubility), therefore the substance is non-toxic at the limit of LoS and NOEC is >LoS.

A reliable NOEC value of 450 mg/L has been calculated for the effects of the test substance towards Green Algae and Aquatic plants. Therefore the test substance has been predicted to be non toxic at the limit of solubility, so the NOEC is 0.045 mg/L. Predicted to be non-toxic at the limit of solubility.

The water solubility of the Alcohols, C16-18 is 0.0412 mg/l at 25 degC (experimental database). This is about 10000 times the water solubility of the test substance.

Description of key information

A 96 h LC50 value of 0.054 mg/L has been calculated for the effects of the test substance on the mortality of the Green Algae and Aquatic plants. This result signifies that the test substance is not expected to be toxic at the limit of solubility. This result is above the LoS (limit of solubility), therefore the substance is non-toxic at the limit of LoS and LC50 is >LoS.
A reliable 96 h LC50 value of 540 mg/L has been calculated for the effects of the test substance towards Green Algae and Aquatic plants. Therefore the test substance has been predicted to be non toxic at the limit of solubility, so the LC50 is 0.054 mg/L. Predicted to be non-toxic at the limit of solubility.
A NOEC value of 0.045 mg/L has been calculated for the effects of the test substance on the mortality of the Green Algae and Aquatic plants. This result signifies that the test substance is not expected to be toxic at the limit of solubility. This result is above the LoS (limit of solubility), therefore the substance is non-toxic at the limit of LoS and NOEC is >LoS.
A reliable NOEC value of 450 mg/L has been calculated for the effects of the test substance towards Green Algae and Aquatic plants. Therefore the test substance has been predicted to be non toxic at the limit of solubility, so the NOEC is 0.045 mg/L. Predicted to be non-toxic at the limit of solubility.
The water solubility of the Alcohols, C16-18 is 0.0412 mg/l at 25 degC (experimental database). This is about 10000 times the water solubility of the test substance.

Key value for chemical safety assessment

EC50 for freshwater plants:: 540 mg/L
EC50 for marine water plants:: 54 mg/L
EC10 or NOEC for freshwater plants:: 450 mg/L
EC10 or NOEC for marine water plants:: 45 mg/L

Additional information

The water solubility of the Alcohols, C16-18 is 0.0412 mg/l at 25 degC (experimental database). This is about 10000 times the water solubility of the test substance.

The available data for saltwateraquatic plants other than algae are limited and to obtaine the value for PNECs for saltwaters is taken account a assesment factor 10 to extrapolate to LC50 following the “Guidance on Information Requirement and Chemical Safety Assessment R.10: Characterisation of dose [concentration]- response for environment”and “Table R.10-5 Assessment factors proposed for deriving PNEC water for saltwater for different data sets”, to account for the possibility that greater taxonomic diversity in the marine environment makes it likely that some marine taxa may be more sensitive than the most sensitive freshwater taxa

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