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EC number: 203-906-6
CAS number: 111-77-3
It should be noted that the zebra fish model does not have metabolic
capacity, which explains why methoxyethanol produced no effects. It is
well established that the proximate toxicant is the acid metabolite and
not the parent glycol ether. This study established that the acid
metabolite of DEGME does not appear to share the same developmental
toxicity characteristics as MAA.
2-(2-methoxyethoxy)acetic acid, the main metabolite of
2-(2-methoxyethoxy)ethanol was evaluated using the zebrafish
embryotoxicity test (ZET) usingt a modified protocol desinge as fast and
simple method to study chemical toxicity after exposure of the complete
vertebrate embryo during embryogenesis in ovo. The protocol included a
novel quantitative evaluation method to assess the development of the
zebrafish embryo based on specific endpoints in time, the general
morphology score (GMS) system , and a teratogenic evaluation using
separate scoring system based on that used for whole embryo cultures.
Methoxyethoxy acetic acid did not show any evidence of developmental
toxicity up to the maximum tested dose of 10mM. In contrast, the know
methoxyacetic acid and ethoxyacetic acid caused both growth retardation
and malformations. A comparison of the results obtained with this
substance and the others tested with the available mammalian
developmental toxicity data showed the potency ranking of the compounds
within their class in the ZET was comparable to their in vivo ranking.
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