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EC number: 203-906-6
CAS number: 111-77-3
No irritation response observed in range finding tests therefore the
maximum concentrations were used for the main study. There was no effect
on body weight. Due to strong irritation reactions of the skin after
intradermal injection with FCA (both with and without test substance),
10% sodium dodecylsuphate was not applied at day 6. After removal of the
patches on day 10, severe erythema dand oedema, indurated, scabbed and
encrusted skin as well as necrosis was observed at the sites previously
treated with FCA. Application sites treated with test substance or
isotonic saline alone showed no signs of irritation.
In a guinea pig maximisation study conducted to current guidelines, 2
-(2 -methoxyethoxy)ethanol showed no signs of a causing a sensitisation
response. Intradermal induction was performed using 5% substance in
isotonic saline and dermal induction and challenge exposures used
undiluted material. There was no evidence of any irritant response
either during the range finder studies.
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