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EC number: 203-906-6
CAS number: 111-77-3
Derivation of assessment factor
There appear to be a number of reasons to deviate from the standard
assessment factor of 1000 normally used when only 3 acute toxicity
values are available. These are listed below:
Note that this assessment factor is consistent with that derived in the
EU risk assessment for this substance (EU 1999).
Formula for the calculation of PNECsed using the equilibrium
partitioning approach for sediment:
PNEC(sed) = (Ksusp-water x PNEC(aqua) / RHOsed) * 1000 - equation R.10
-2 of guidance
PNEC(sed) Predicted No Effect Concentration in sediment [mg/kg, wet
Ksusp-water partition coefficient suspended matter / water [0.926 m3/m3]
- equation R16 -13 of guidance
RHOsed bulk density of sediment matter [1150kg/m3] - equation R.10 -2 of
PNECaqua Predicted No Effect Concentration in water [as above]
Formula for the calculation of PNECsoil using the equilibrium
partitioning approach for soil:
PNEC(soil) = (Ksoil-water x PNEC(aqua) / RHOsoil) * 1000 - equation R10
-2 of guidance
PNEC(soil) Predicted No Effect Concentration in sediment [mg/kg, wet
Ksoil-water partition coefficient sediment / water [0.306 m3/m3] -
equation R16 -13 of guidance
RHOsoil bulk density of soil matter [1700 kg/m3] - calculated from
composition information in table R16 -11 of guidance
The PNEC oral is derived using the critical oral mammalian NOAEL (in
mg/kg bw ) as a starting point. This is then converted to a NOEC (in
mg/kg food) using the conversion factors in table R10-12 of the guidance
from which the PNEC is derived by using the appropriate assessment
factor in table R10 -13.
The very low toxicity of 2 -(2 -methoxyethoxy)ethanol to aquatic species
coupled with its ready biodegradability mean that it does not meet the
criteria for classification.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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