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Registration Dossier
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Diss Factsheets
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EC number: 205-288-3 | CAS number: 137-30-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Specific investigations: other studies
Administrative data
- Endpoint:
- biochemical or cellular interactions
- Type of information:
- experimental study
- Adequacy of study:
- disregarded due to major methodological deficiencies
- Reliability:
- 3 (not reliable)
- Rationale for reliability incl. deficiencies:
- significant methodological deficiencies
Data source
Reference
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 1 992
Materials and methods
Test guideline
- Qualifier:
- no guideline available
- GLP compliance:
- no
- Type of method:
- in vivo
- Endpoint addressed:
- not applicable
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- not specified
Examinations
- Examinations:
- Isoelectric focusing (IEF) of serum samples incubated with 125-I-labelled T4
Results and discussion
Any other information on results incl. tables
IEF study of TBG microheterogeneity during ontogenesis
Serum from rats of different ages, from 19-day embryos to 60-day post-natal animals, was incubated with radioiodinated T4 and then submitted to IEF in the pH range 4-5 (Fig. 1). The age-related labelling density pattern of the TBG zone on the autoradiogram was consistent with the developmental trend of the protein, as demonstrated in previous binding, immunological and biosynthetic studies: absence in the foetus, appearance and increasing concentration in neonates, then decline and finally disappearance in young adults. The weak labelling of transthyretin (TTR) in the growing pups reflects the successful competition of the co-existing TBG for the common T4 ligand.
The polymorphism of TBG, first observed in serum from 8-day-old rats, is maintained throughout development, with respect to both number and isoelectric points (pl) of isoforms.
The protein is separated into six bands with pl values between 4.25 and 4.55. The distribution of the T4 ligand among TBG isoforms is uneven at all ages. Moreover, this pattern of unequal labelling markedly changes during ontogenesis: in the neonates, the greatest labelling is seen with the most alkaline bands, but with increasing age of the animals it shifts gradually tot the most acidic bands.
Applicant's summary and conclusion
- Conclusions:
- Thyroxine-binding globulin (TBG), the major carrier of thyroid hormones in human and murine sera, is in the rat a developmentally regulated protein, showing a large surge during post-natal growth followed by virtual disappearance in adults.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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