2-aminoethanol

Acute Toxicity: inhalation

Administrative data

Endpoint:

acute toxicity: inhalation

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

test procedure in accordance with national standard methods with acceptable restrictions

Remarks:

Substance concentration was not measured.

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1988

Report date:

1988

Materials and methods

Test guideline

Qualifier:

no guideline followed

Principles of method if other than guideline:

Five animals per sex were exposed to substantially saturated vapor for 6 hours using a static exposure system.

GLP compliance:

yes

Test type:

other: inhalation hazard test

Limit test:

yes

Test material

Test material information

Constituent 1

Reference substance name:

2-aminoethanol

EC Number:

205-483-3

EC Name:

2-aminoethanol

Cas Number:

141-43-5

Molecular formula:

C2H7NO

IUPAC Name:

2-aminoethanol

Test material form:

liquid

Test animals

Species:

rat

Strain:

Sprague-Dawley

Sex:

male/female

Details on test animals or test system and environmental conditions:

TEST ANIMALS
- Weight at study initiation: 200 - 300 g
- Fasting period before study: none
- Diet: commercial appropriate diet ad libitum
- Water: municipal water ad libitum

Administration / exposure

Route of administration:

inhalation: vapour

Type of inhalation exposure:

not specified

Vehicle:

air

Details on inhalation exposure:

GENERATION OF TEST ATMOSPHERE / CHAMBER DESCRIPTION
The vapor was produced by enclosing approximately 100 g of the test material in a sealed 100 to 151 liter animal chamber for approximately 18 hours under static conditions. A mixing fan periodically agitated the chamber atmosphere to aid in distribution of the vapour. Oxygen was added, as needed to maintain a chamber oxygen content of approximately 20%. The temperature was maintained at 25 degrees C.

Analytical verification of test atmosphere concentrations:

not specified

Duration of exposure:

6 h

No. of animals per sex per dose:

5 males, 5 females

Control animals:

no

Details on study design:

- Duration of observation period following administration: 14 days
- Frequency of weighing: day 0, 7 and 14
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, body weight

Results and discussion

Effect levels

Effect levels 1

Key result

Sex:

male/female

Dose descriptor:

LC50

Effect level:

> 1.3 mg/L air

Exp. duration:

6 h

Effect levels 2

Sex:

male/female

Dose descriptor:

LC0

Effect level:

ca. 1.3 mg/L air

Based on:

test mat.

Exp. duration:

6 h

Remarks on result:

other: Value derived from theoretical saturated vapor concentrations of monoethanolamine at room temperature and was not measured during the experiment.

Mortality:

There were no deaths noted for males or females exposed to the highest concentration achievable for 6 hours.

Clinical signs:

other: There were no signs of toxicity noted for males or females exposed to the highest concentration achievable for 6 hours.

Body weight:

Nothing abnormal reported.

Gross pathology:

The necropsy findings noted nothing remarkable in males or females.

Any other information on results incl. tables

The theoretical saturated vapor concentration of monoethanolamine at room temperature is 520 ppm (1.3 mg/L). The LC50 is greater than 520 ppm (Reviews of Environmental Contamination and Toxicology, Vol. 149, 1997.)

Applicant's summary and conclusion

Interpretation of results:

GHS criteria not met