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Environmental fate & pathways

Henry's Law constant

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Administrative data

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Description of key information

From the water surface, the substance will not evaporate into the atmosphere.

Key value for chemical safety assessment

Additional information


In Article 13 of Regulation (EC) No 1907/2006, it is laid down that information on intrinsic properties of substances may be generated by means other than tests, provided that the conditions set out in Annex XI (of the same Regulation) are met. 

According to Annex XI of Regulation (EC) No 1907/2006 (Q)SAR results can be used if (1) the scientific validity of the (Q)SAR model has been established, (2) the substance falls within the applicability domain of the (Q)SAR model, (3) the results are adequate for the purpose of classification and labeling and/or risk assessment and (4) adequate and reliable documentation of the applied method is provided.

For the assessment of 2 -aminoethanol (MEA, CAS 141 -43 -5), (Q)SAR results were used for the estimation of the Henry’s Law constant. The criteria listed in Annex XI of Regulation (EC) No 1907/2006 are considered to be adequately fulfilled and therefore the endpoint(s) sufficiently covered and suitable for risk assessment.

Therefore, further experimental studies on the Henry’s Law Constant are not provided.


The Henry's law constant at 25 °C was estimated to be 3.73E-5 Pa*m³/mol using SRC HENRYWIN v3.20 (BASF, 2014). The substance was within the estimation domain of the model. The HENRYWIN estimate refers to the uncharged molecule. The calculation of the Henry's Law constant via measured data for vapour pressure and water solubility is not taken into consideration as the method is not valid for substances like MEA which are miscible with water. The resulting HLC is 3.1E-3 Pa*m³/mol (BASF, 2014), but the value is disregarded. The estimated HLC value of the bond estimation method indicates that the substance will not evaporate into the atmosphere. However, most of the molecules of the test item will be present in a protonated form under environmental relevant pH conditions (pKa = 9.5).

It can be concluded that the substance will not evaporate into the atmosphere from the water surface as the HLC is < 1 Pa*m³/mol.