Registration Dossier
Registration Dossier
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EC number: 256-905-8 | CAS number: 51000-52-3
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Not a GLP study, not many details on the study design and the documentation of the study not sufficient in assessment.
Data source
Referenceopen allclose all
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 2 007
- Reference Type:
- other: Unpublished report
- Title:
- Unnamed
- Year:
- 1 977
Materials and methods
- Principles of method if other than guideline:
- Other
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- Vinyl neodecanoate
- EC Number:
- 256-905-8
- EC Name:
- Vinyl neodecanoate
- Cas Number:
- 51000-52-3
- Molecular formula:
- C12H22O2
- IUPAC Name:
- vinyl neodecanoate
- Details on test material:
- As per Vinyl Neodeconoate IUCLID 4 Data Set
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- Adult male and female Wistar rats aged 12 weeks were used in this experiment
Administration / exposure
- Route of administration:
- oral: gavage
- Details on oral exposure:
- Rats were dosed with undiluted vinyl neodecanoate by intraesophageal intubation.
- Doses:
- 1.25, 2.5, 5.0, 10 ml/kg
- No. of animals per sex per dose:
- 2
- Details on study design:
- Adult male and female Wistar rats aged 12 weeks were used in this experiment. Rats were dosed with undiluted vinyl neodecanoate at (1.25, 2.5, 5.0, 10 ml/kg) by intraesophageal intubation. Food and water were freely available throughout a 9 day observation period.
- Statistics:
- No data
Results and discussion
Effect levels
- Dose descriptor:
- LD50
- Effect level:
- > 10 mL/kg bw
- Mortality:
- None
- Clinical signs:
- other: None
- Gross pathology:
- No data
- Other findings:
- No data
Any other information on results incl. tables
Based on the experimental results, the acute oral LD50 was estimated to be greater than 10 ml/kg or correcting for density of the test substance, > 8850 mg/kg bw.
Applicant's summary and conclusion
- Interpretation of results:
- relatively harmless
- Remarks:
- Migrated information
- Conclusions:
- Vinyl neodecanoate is of low acute toxicity to laboratory rats by the oral routes of exposure.
- Executive summary:
Laboratory rats (2/sex/group) were treated with Vinyl Neodecanoate by oral gavage to determine the acute oral LD50 value. No mortality or clinical signs were observed. The estimated oral LD50 value for laboratory rats was > 8850 mg/kg of body weight.
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