Registration Dossier
Registration Dossier
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EC number: 686-526-7 | CAS number: 171611-11-3
Genetic toxicity: in vivo
Administrative data
- Endpoint:
- in vivo mammalian somatic and germ cell study: gene mutation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2017.10.24~2018.01.26
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 018
- Report date:
- 2018
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 474 (Mammalian Erythrocyte Micronucleus Test)
- Version / remarks:
- July 29,2016
- GLP compliance:
- yes
- Type of assay:
- mammalian erythrocyte micronucleus test
Test material
- Reference substance name:
- Lithium bis(fluorosulfonyl)imide
- EC Number:
- 686-526-7
- Cas Number:
- 171611-11-3
- Molecular formula:
- F2 H N O4 S2 . Li
- IUPAC Name:
- Lithium bis(fluorosulfonyl)imide
- Test material form:
- solid: bulk
Constituent 1
Test animals
- Species:
- mouse
- Strain:
- other: CrljOri:CD1 (ICR), Mouse
- Details on species / strain selection:
- CrljOri:CD1 (ICR), Mouse, SPF
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- Temperature : (22 ± 3) celsius
Relative humidity : (50 ± 20) % R.H.
Air exchange : (10 – 20) times/h
Administration / exposure
- Route of administration:
- intraperitoneal
- Vehicle:
- Sterile distilled water(SDW)
Doses / concentrations
- Dose / conc.:
- 400 mg/kg bw/day (nominal)
- Remarks:
- Negative control : 0
- Test subs : 100~400mg/mL
- Positive control : 70
- No. of animals per sex per dose:
- Neg : 5(Dose : 0mg/kg B.W/day)
Subs : 20(5X4 group), (Dose : 100~400mg/kg B.W/day)
Pos : 5(Dose : 70mg/kg B.W/day) - Control animals:
- yes
- Positive control(s):
- Dose : 70mg/kg B.W day
Concentration : 7 mg/mL
Volume : 10mL/kg/times
Times : 1 times
Route : Intraoerutioneal
No. of animals : 5
Results and discussion
Test results
- Key result
- Sex:
- male
- Genotoxicity:
- negative
- Toxicity:
- no effects
Applicant's summary and conclusion
- Conclusions:
- the test substance, LiFSI, was determined not to induce an increased
frequency of micronuclei in the bone marrow cells of male ICR mice under the
present experimental condition.
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