Registration Dossier
Registration Dossier
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EC number: 686-526-7 | CAS number: 171611-11-3
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation / corrosion, other
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2017.9.28~2017.11.27
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 017
- Report date:
- 2017
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- GLP compliance:
- yes (incl. QA statement)
Test material
- Reference substance name:
- Lithium bis(fluorosulfonyl)imide
- EC Number:
- 686-526-7
- Cas Number:
- 171611-11-3
- Molecular formula:
- F2 H N O4 S2 . Li
- IUPAC Name:
- Lithium bis(fluorosulfonyl)imide
- Test material form:
- solid: bulk
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or test system and environmental conditions:
- Yac:NZW(KBL), Rabbit, SPF
Results and discussion
In vivo
Results
- Irritation parameter:
- erythema score
- Basis:
- animal:
- Time point:
- 24/48/72 h
- Score:
- ca. 2.7
- Max. score:
- 4
- Reversibility:
- not reversible
- Irritant / corrosive response data:
- Mean score of skin reaction (Erythem a and
Eschar) was calculated as "0.0", "2.7", "2.7", respectively.
Applicant's summary and conclusion
- Interpretation of results:
- Category 2 (irritant) based on GHS criteria
- Conclusions:
- No clinical signs and mortality were observed relating to test substance treatment.
In body weight, the weight decrease was observed in all animals on 72 hours after
administration as compared with administration weight. Considering the skin irritation
observed during the experiment period, this sign was considered to be test
substance-related effect.
After removal of the test substance patches, the observed skin reactions were all
recovered within 10 days and reversibility was confirmed. It was considered to be the
effect of test substance administration. Mean score of skin reaction (Erythem a and
Eschar) was calculated as "0.0", "2.7", "2.7", respectively.
According to the criteria for the evaluation of skin reactions specified by the Globally
Harmonized System of Classification and Labelling of Chemicals(GHS), the present
observation provides it caused severe skin irritation. LiFSI was classified as "Irritant
(Category 2)" on this study.
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