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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
acute toxicity: dermal
Type of information:
experimental study
Adequacy of study:
key study
Study period:
2018.04.16~2018.06.19
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2018
Report date:
2018

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
OECD Guideline 402 (Acute Dermal Toxicity)
Version / remarks:
Fixed dose procedure(adopted : 9 OCT 2017)
Deviations:
not specified
GLP compliance:
yes
Test type:
fixed dose procedure

Test material

Constituent 1
Chemical structure
Reference substance name:
Lithium bis(fluorosulfonyl)imide
EC Number:
686-526-7
Cas Number:
171611-11-3
Molecular formula:
F2 H N O4 S2 . Li
IUPAC Name:
Lithium bis(fluorosulfonyl)imide
Test material form:
solid: bulk

Test animals

Species:
rat
Strain:
Crj: CD(SD)
Sex:
female
Details on test animals or test system and environmental conditions:
Animal species(strain) : Crl:CD(SD), Rat, SPF
- 9 females

Administration / exposure

Type of coverage:
not specified
Vehicle:
other: Sterile distilled water
Details on dermal exposure:
The test substance was applied uniformly over an area which was approximately 10 % [rat : (4 × 4) cm2] of the total body surface area.
Vehicle and test substance were held in contact with the skin with a porous gauze dressing and non-irritating tape(Tegarderm, 3M)
Duration of exposure:
24hr
Doses:
200/1000/2000(mg/kg B.W)
No. of animals per sex per dose:
Female(1) : 200mg/kg B.W - (Range Finding study)
Female(1) : 1000mg/kg B.W - (Range Finding study)
Female(1) : 2000mg/kg B.W - (Range Finding study)
Female(2) : 2000mg/kg B.W - (Main study)
Control animals:
not specified
Details on study design:
On the day prior to the application, the back of each animals was clipped free of hairs.
The test substance was applied uniformly over an area which was approximately 10 % [rat : (4 × 4) cm2] of the total body surface area.
Vehicle and test substance were held in contact with the skin with a porous gauze dressing and non-irritating tape(Tegarderm, 3M) during a 24-hour exposure period.
The wrappings and the adhesive bands were removed at 24 hours after application.
The applied sites were washed out gently with Sterile distilled water(for injection).

Results and discussion

Effect levels
Key result
Sex:
female
Dose descriptor:
LD50
Effect level:
> 2 000 - < 5 000 mg/kg bw
Based on:
test mat.
Mortality:
The test substance-related dead animals were not observed during study period.
Clinical signs:
other: The test substance-related dead animals were not observed during study period. - Range-Finding study In clinical signs, convulsion(2301 : day 1), soiled perineal region(2301 : day 1 – 4), lying on side(2301 : day 1), jumping(2301 : day 2), opisthotonus(23
Gross pathology:
At the necropsy, there were no abnormal findings caused by administration of the test
substance.

Applicant's summary and conclusion

Interpretation of results:
Category 5 based on GHS criteria
Conclusions:
Based on these results, LiFSI was classified into GHS (Globally Harmonized Classification System for Chemical Substances and Mixtures)
Category 5 (2000 mg/kg body weight < LD50 < 5000 mg/kg body weight) in this study.