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EC number: 686-526-7 | CAS number: 171611-11-3
Eye irritation
Administrative data
- Endpoint:
- eye irritation, other
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2017.9.27-2017.11.27
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 017
- Report date:
- 2017
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 405 (Acute Eye Irritation / Corrosion)
- GLP compliance:
- yes (incl. QA statement)
Test material
- Reference substance name:
- Lithium bis(fluorosulfonyl)imide
- EC Number:
- 686-526-7
- Cas Number:
- 171611-11-3
- Molecular formula:
- F2 H N O4 S2 . Li
- IUPAC Name:
- Lithium bis(fluorosulfonyl)imide
- Test material form:
- solid: bulk
Constituent 1
Test animals / tissue source
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or tissues and environmental conditions:
- Yac:NZW(KBL), Rabbit, SPF
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- cornea opacity score
- Basis:
- animal #1
- Time point:
- 72 h
- Score:
- > 0.3 - < 1
- Max. score:
- 1
- Irritation parameter:
- cornea opacity score
- Basis:
- animal #2
- Time point:
- 72 h
- Score:
- > 1 - < 2
- Max. score:
- 2
- Irritation parameter:
- cornea opacity score
- Basis:
- animal #3
- Time point:
- 72 h
- Score:
- > 1 - < 2
- Max. score:
- 2
- Irritant / corrosive response data:
- Mean score of eye reactions were as follows; [1101(Cornea opacity : 1.0, Conjunctivae
redness : 1.0, Chemosis swelling : 0.3), 1102(Cornea opacity : 2.0, Conjunctivae
redness : 1.0, Chemosis swelling : 1.0), 1103(Cornea opacity : 2.0, Conjunctivae
redness : 1.0, Chemosis swelling : 1.0)].
Applicant's summary and conclusion
- Interpretation of results:
- Category 1 (irreversible effects on the eye) based on GHS criteria
- Conclusions:
- Mean score of eye reactions were as follows; [1101(Cornea opacity : 1.0, Conjunctivae
redness : 1.0, Chemosis swelling : 0.3), 1102(Cornea opacity : 2.0, Conjunctivae
redness : 1.0, Chemosis swelling : 1.0), 1103(Cornea opacity : 2.0, Conjunctivae
redness : 1.0, Chemosis swelling : 1.0)].
According to the criteria for the evaluation of eye reactions specified by the Globally
Harmonized System of Classification and Labelling of Chemicals(GHS), the present
observation provides it caused severe eye irritation. LiFSI was classified as "Category 1"
on this study.
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