Amines, C12-14-alkyl, C6-10-alkyl phosphates

Water solubility

Link to relevant study record(s)

Reference

Endpoint:

water solubility

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Qualifier:

according to guideline

Guideline:

OECD Guideline 105 (Water Solubility)

Deviations:

not specified

GLP compliance:

no

Type of method:

flask method

Key result

Water solubility:

< 353 mg/L

Conc. based on:

other: the total water solubility of the four components measured

Incubation duration:

ca. 5 d

Temp.:

25 °C

pH:

ca. 2.25

Summary of Results

Solution	Bis (2-ethyl hexyl) hos hate		2-ethylhexyl hos hate		Dodecylamine		2-ethylhexyl hexyl hos hate
	(min)	Reported value m IL	(min)	Reported value m IL	(min)	Reported value m IL	(min)	Reported value m IL
Water Solubility da 1	8.96		2.68	336	10.99	17	7.80
Water Solubility da 2	8.96		2.68	325	11.02	24	7.80
Water Solubility da 3	8.96	<5	2.65	306	1 1.05	20	7.80
Water Solubility da 4	8.96	<5	2.65	315	11.02	19	7.80
Water Solubility	8.93		2.65	295	11.07	19	7.80

No significant peaks were detected in the solvent control data.

Conclusions:

For bis (2-ethyl hexyl) phosphate, 2-ethylhexyl phosphate and dodecylamine results from
tests 4 and 5 indicate that there is no increasing solubility over time; therefore, the mean
results from tests 1, 2 and 3 are reported. Mean results from all 5 days are also calculated
for information.

As a result, the total water solubility of the four components measured (greater than 10% by
LC-MS area%) is < 353 mg/l. The total water solubility value does not include assessment
of solubility of minor components.
For 2-ethylhexyl phosphate, triplicate results are <15% from day 1, 2 and 3, therefore
satisfactory.
Variation for dodecylamine for day 1, 2 and 3 is outside 15% but this is considered to be
insignificant at this Iew Ievei and results for day 4 and 5 show consistency.
An additional component was detected in the octanol layer from the partition coefficient
analysis. This was assigned as 2-ethylhexyl hexyl phosphate but was not detected (<5
mg/L) in the water solubility test.
The data contained in this report has been generated in a Iabaratory holding a current
statement of GLP Compliance, issued by the UK GLP Monitaring Authority, MHRA, but not
as part of a formal GLP study.

Executive summary:

For bis (2-ethyl hexyl) phosphate, 2-ethylhexyl phosphate and dodecylamine results from tests 4 and 5 indicate that there is no increasing solubility over time; therefore, the mean results from tests 1, 2 and 3 are reported. Mean results from all 5 days are also calculated for information.

Test Solution	Mean value m IL
	Bis (2-ethyl hexyl) hos hate	2-ethylhexyl hos hate	Dodecylamine		2-ethylhexyl hexyl hos hate
Day 1,2,3	<5	322	21		<5
All 5 days	<5	315	21		<5

As a result, the total water solubility of the four components measured (greater than 10% by LC-MS area%) is < 353 mg/L. The total water solubility value does not include assessment of solubility of minor components.

For 2-ethylhexyl phosphate, triplicate results are <15% from day 1, 2 and 3, therefore satisfactory.

Variation for dodecylamine for day 1, 2 and 3 is outside 15% but this is considered to be insignificant at this low level and results for day 4 and 5 show consistency.

An additional component was detected in the octanol layer from the partition coefficient analysis. This was assigned as 2-ethylhexyl hexyl phosphate but was not detected (<5 mg/L) in the water solubility test.

The data contained in this report has been generated in a laboratory holding a current statement of GLP Compliance, issued by the UK GLP Monitoring Authority, MHRA, but not as part of a formal GLP study.

Description of key information

The water solubility was determined according to OECD Guideline 105.

Key value for chemical safety assessment

Water solubility:

353 mg/L

at the temperature of:

20 °C

Additional information

The total water solubility of all four components of the test substance was determined to be less than 353 mg/L.