Registration Dossier
Registration Dossier
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EC number: 201-159-0 | CAS number: 78-93-3
Endpoint summary
Administrative data
Key value for chemical safety assessment
Additional information
According to the data provided in the REACH dossier of butanone, dissiminated on the ECHA homepage, butanone is not mutagenic in bacteria, mammalian cells in vitro or in mammals.
AMES (S. typ. TA 1535, TA 1537, TA 1538, TA 98, TA 100): negative
Mouse lymphoma assay (L5178Y cells): negative
Chromosomal abberation test in vitro (rat liver RL4 cell line): negative
Unscheduled DNA synthesis test in vitro(rat hepatocytes): negative
Cell transformation assay (BALB/3T3): negative
Micronucleus test in vivo (mouse): negative
Further data from secondary sources (MAK documentation of the Deutsche Forschungsgemeinschaft-DFG) reported, that butanone has been tested negative in E. coli strains WP2, WP2uvrA and in S. typ. strain TA102.
Endpoint Conclusion:
Justification for classification or non-classification
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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