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EC number: 219-702-5
CAS number: 2500-88-1
The acute toxicity of the test item Hostanox SE 10 P to fish (zebrafish)
was determined according to OECD-Guideline for Testing of Chemicals No.
A semi-static limit test with daily renewal of the test media was
conducted with the water accommodated fraction (WAF) of 100 mg/L.The
water accommodated fraction was preparedwith a nominal
loading of 100 mg/L test item Hostanox SE 10 P with dilution water after
-48, -24, 0 and 24 h of exposure. The WAF was stirred for 48 hours with
a magnetic stirrer at room temperature. After a separation phase of 1
hour the WAF was taken from the homogeneous liquid phase.Duration of the
test was 96 h. 7 test organisms were exposed to the limit loading and
the control. Water quality parameters pH-value, temperature and
oxygen-saturation measured after 0, 24, 48, 72 and 96 h were determined
to be within the acceptable limits.
No analytical evaluation of the limit loading level and the
control was carried out since no suitable method for determination of
the test item could be established.
In this study Hostanox SE 10 P did not cause any effects to
zebrafish after 96 h when tested in a limit test with the water
accommodated fraction of nominal 100 mg/L.
In the acute immobilization test with Daphnia magna (STRAUS)
the effects of the saturated solution of the test item Hostanox SE 10 P
with a nominal loading of 100 mg/L as limit concentration were
determined according to OECD 202 (2004). The limit test was conducted
under semi-static conditions over a period of 48 h. Twenty daphnids were
exposed to the saturated solution and the control. No analytical
evaluation of the saturated solution was carried out since no suitable
method for determination of the test item could be established.All
effect values given are based on the nominal loading of the test item
Hostanox SE10 P. The water quality
parameters (pH-value and dissolved oxygen concentration), measured at 0,
24 and 48 h, were determined to be within the acceptable limits. The
validity criteria of the test guideline were fulfilled.
At the saturated solution with a
nominal loading of 100 mg/L of the test itemHostanox SE 10
P,no effect was observed onDaphnia
TheDaphnia magnaReproduction Test (Semi-Static, 21 days)of
Hostanox SE 10 P was conducted as limit test with a nominal loading of
100 mg/L Hostanox SE 10 Paccording to OECD 211 (2008).
Ten daphnids individually held were used for the limit loading
level of 100 mg/L and the control. At test start the daphnids were 2 to
24 h old. The test method was semi-static with a daily renewal of the
test solutions. The aim of the Daphnia Reproduction Test over 21 days
was to assess effects on the reproduction capacity and other test
item-related effects, including occurrence of aborted eggs and stillborn
juveniles, time of production of first brood, adult mortality, intrinsic
rate of natural increase, dry body weight and length of the parent
daphnids. No analytical evaluation of the limit loading level was
carried out since no suitable method for determination of the test item
could be established. The results given are based on the nominal loading
level of 100 mg/L of the test item Hostanox SE 10 P.
The average values
of juveniles per parental daphnid were
126 for the control and 120 for the limit loading level of 100 mgHostanox
SE 10 P/L after 21 days. The
reproductive output of daphnids in the loading level was comparable to
the output of daphnids in the control(t-test,p = 0.05).
The coefficient of variation of the number
of living offspring produced per
parent was 8 % for the control and 7 % for the limit loading level of
The intrinsic rates of natural increase
(IR) of the surviving parent daphnids accounting for generation time
and number of offspring were calculated as a measure for population
growth and maintenance. The IR of the limit loading level of 100 mg/L
control group (t-test,p = 0.05).
No adult mortality or
immobilization of parental daphnids was observedin
the control andthe limit
loading level of 100 mg/L.
Related to the total number of produced
juveniles (dead + alive) the percentage ofdead juveniles and aborted
eggswas lower than 1 % in the limit loading level of 100 mg/L, which
is seen to be not biologically significant. In the control no dead
juveniles or aborted eggs were observed.
Five broods, respectively, were
observed during the test period for all parental daphnids. The first
brood was released from all parental daphnids inthelimit
loading level of 100 mg/Land the control by day 9.
and ephippia (winter eggs)
were observed in the respective control or test groups.
At the limit loading level with 100 mg Hostanox SE 10 P/L no
biologically or statistically significant effects were determined. The
No Observed Effect Level (NOEL) and the Lowest Observed Effect Level
(LOEL) were as follows: NOEL: 100 mg/L, LOEL: > 100 mg/L.
The endpoints were assessed based on the nominal loading of the
test item Hostanox SE 10 P.
The toxicity of Hostanox
SE 10 P to the unicellular freshwater green alga Desmodesmus
subspicatus was determined
according to the principles of OECD 201.The aim of the
study was to assess the effects on growth rate and yield over a period
of 72 hours. Based on a preliminary range finding test, a limit test
with a water accommodated fraction (WAF) was carried out.The
water accommodated fraction was preparedwith a nominal
loading of 100 mg/L test item Hostanox SE 10 P.Sixreplicates
were tested for the limit concentration and the control.Environmental
conditionswere determined to be within
the acceptable limits.No analytical evaluation of the limit
loading level and the control was carried out since no suitable method
for determination of the test item could be established. All effect
valuesofHostanox SE 10 P
are given based on the nominal test item loading.
In this study no inhibition on growth of the freshwater green alga
Desmodesmus subspicatus was found after 72 hours exposure to the test
item Hostanox SE 10 P. The NOEL for inhibition of specific growth rate
and yield after 72 hours was 100 mg/L.
A Respiration Inhibition Test with activated sludgeaccording
to OECD Guideline No. 209 (2010) was carried out with the test item
Hostanox SE 10 P.Test
system was activated sludge of a municipal treatment plant. The test was
carried out under static conditions with the limit concentration 1000
mg/L. The respiration rates of the control, reference and test item
replicates were measured after a contact time of three hours, and the
inhibitory effects of the test and reference item were determined in
comparison to the control respiration rates. The inhibition of
respiration for the test item replicates ranged from -5 to 0 %.
Hostanox SE 10 P caused no inhibiting effects on activated sludge
of a municipal sewage treatment plant at the limit concentration of 1000
mg/L. The NOEC of the test item Hostanox SE 10 P is1000mg/L.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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