Registration Dossier
Registration Dossier
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EC number: 219-702-5 | CAS number: 2500-88-1
Endpoint summary
Administrative data
Link to relevant study record(s)
Description of key information
Dioctadecyl disulphide applied by gavage to rats was mainly excreted via feces (range: 87.7 - 93 %) indicating a very limited bioaccessibility.Half-life in blood was from 9.6 to 14 hours. Low concentrations of the test substance were found in mesentheric lymph nodes, kidneys and liver.
Key value for chemical safety assessment
- Bioaccumulation potential:
- low bioaccumulation potential
Additional information
The dispositon of Hostanox SE 10 was investigated in male Wistar rats after single oral doses of 100 and 1000 mg/kg bw. A dose-dependent increase in blood concentration of Hostanox SE 10 was observed and Hostanox SE 10 was cleared from blood within a parent half-life of 14 hours. Maximum blood concentrations of Hostanox SE 10 were reached within 6 hours and were 250 pmol/mL blood. Low concentrations of the test item were also observed in liver, kidney and mesentheric lymphnodes. The data indicate that Hostanox SE 10 absorption from the gastro-intestinal tract is very limited after oral administration and that the absorbed amount of the substance is rapidly cleared from blood. Most of the administered dose (93 +/- 14 %) was recovered in feces within 72 h supporting the observed low bioaccessibility.
The dispositon of Hostanox SE 10 was investigated in male Wistar rats after a single oral dose of 49.5 mg/kg bw. Hostanox SE 10 was cleared from blood within a parent half-life of 9.6 hours. Maximum blood concentration of Hostanox SE 10 was reached 3 hours after application in one of three rats and was 0.18 µg/mL blood. Low concentrations of the test item (< 0.7 or < 0.1 µg/g) were also observed in fat tissue, spleen, heart, pancreas, liver, kidney and mesentheric lymphnodes. The highest concentration was found in adrenals (1.5 µg/g). The data indicate that Hostanox SE 10 absorption from the gastro-intestinal tract is very limited after oral administration and that the absorbed amount of the substance is rapidly cleared from blood. Most of the administered dose (87.7 +/- 10.5 %) was recovered in feces supporting the observed low bioaccessibility.
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