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EC number: 219-702-5
CAS number: 2500-88-1
Animals treated with up to 5000 mg/kg bw/d (2 applications, one daily)
did not show any clinical sign. All animals survived until the study
The number of micronuclei containing polychromatic erythrocytes and
normocytes were not influenced by the treatment with Hostanox SE 10. The
ratio polychromatic erythrocytes/normocytes did not differ to the ratio
obtained from the negative control animals.
Cyclophosphamide (positive control) showed a significant increase of
induced mirconucleus frequency.
In conclusion, it can be stated that during the study the test item did
not induce micronuclei as determined by the micronucleus test in the
bone marrow cells of the mouse.
The test substance was investigated for
its micronuclei formation potential in bone marrow in mice. Each 5 males
and 5 females were treated by gavage at daily doses of 0, 50, 500 and
5000 mg/kg bw for two days. No treatment related clinical effect was
observed. The ratios of polychromatic erythrocytes to normochromatic
erythrocyte were not affected by the treatment. No increase of
micronuclei formation was observed for treated animals.
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