Registration Dossier
Registration Dossier
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EC number: 271-676-4 | CAS number: 68603-84-9
Basic toxicokinetics
Administrative data
- Endpoint:
- basic toxicokinetics
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Study period:
- 2000
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: Handbook, secondary source
Data source
Reference
- Reference Type:
- review article or handbook
- Title:
- Unnamed
- Year:
- 2 001
- Report date:
- 2001
Materials and methods
- Objective of study:
- metabolism
- Principles of method if other than guideline:
- no guideline required
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Nonanoic acid
- EC Number:
- 203-931-2
- EC Name:
- Nonanoic acid
- Cas Number:
- 112-05-0
- Molecular formula:
- C9H18O2
- IUPAC Name:
- nonanoic acid
- Details on test material:
- - Name of test material (as cited in study report): nonanoic acid
Constituent 1
- Radiolabelling:
- not specified
Test animals
- Species:
- other: mammalian species
- Strain:
- not specified
- Sex:
- not specified
Administration / exposure
- Route of administration:
- other: no data
- Vehicle:
- not specified
- Details on exposure:
- no data
- Duration and frequency of treatment / exposure:
- no data
Doses / concentrations
- Remarks:
- Doses / Concentrations:
no data
- No. of animals per sex per dose / concentration:
- no data
- Control animals:
- not specified
Results and discussion
Metabolite characterisation studies
- Metabolites identified:
- not specified
Applicant's summary and conclusion
- Conclusions:
- Interpretation of results (migrated information): no bioaccumulation potential based on study results
The test substance is metabolised in the liver via ß-oxidation. There was no accumulation in tissues. - Executive summary:
Nonanoic acid is metabolized in the liver via beta-oxidation, producing ketone bodies. No chain elongation or tissue storage of the acid was observed in rats. Metabolism of the terminal propionic acid residue resulted in increased glucose and glycogen synthesis (Cragg, 2001).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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