Registration Dossier
Registration Dossier
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EC number: 201-075-4 | CAS number: 78-00-2
Dermal absorption
Administrative data
- Endpoint:
- dermal absorption in vivo
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Study well documented, meets generally accepted scientific principles, acceptable for assessment. Reliability assessment as per that quoted in IUCLID 4 (2000) data review
Data source
Reference
- Reference Type:
- publication
- Title:
- The penetration of lead through the skin
- Author:
- Laug, Kunze
- Year:
- 1 948
- Bibliographic source:
- J. Ind. Hyg. Toxicol. 30, pp 256-259
Materials and methods
- Principles of method if other than guideline:
- Rats (300 - 350 g weight) were contaminated over 29 cm2 skin with TEL at a dose level of 106 mg Pb per rat and observed for adsorption effects over 24 hours
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Tetraethyllead
- EC Number:
- 201-075-4
- EC Name:
- Tetraethyllead
- Cas Number:
- 78-00-2
- Molecular formula:
- C8H20Pb
- IUPAC Name:
- tetraethylplumbane
Constituent 1
- Radiolabelling:
- not specified
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- 300 - 350 g weight
Administration / exposure
- Type of coverage:
- open
- Vehicle:
- unchanged (no vehicle)
- Duration of exposure:
- 24 hours
- Doses:
- Rats were contaminated over 29 cm2 skin with TEL at a dose level of 106 mg Pb per rat
Results and discussion
- Signs and symptoms of toxicity:
- yes
Percutaneous absorption
- Dose:
- 106mg Pb
- Parameter:
- percentage
- Absorption:
- ca. 6.5 %
- Remarks on result:
- other: 24h
- Remarks:
- 6.5% of the applied amount adsorbed into the body of the rats. It is believed that a large proportion (90%) of TEL evaporates from the skin and only a small portion is actually absorbed by the skin.
Applicant's summary and conclusion
- Conclusions:
- 6.5% of the applied amount adsorbed into the body of the rats. It is believed that a large proportion (90%) of TEL evaporates from the skin and only a small portion is actually absorbed by the skin.
- Executive summary:
Rats (300 - 350 g weight) were contaminated over 29 cm2 skin with TEL at a dose level of 106 mg Pb per rat and observed for adsorption effects over 24 hours. TEL penetrates through the skin and is then distributed in the body tissues. 6.5% of the applied amount adsorbed into the body of the rats. It is believed that a large proportion (90%) of TEL evaporates from the skin and only a small portion is actually absorbed by the skin.
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