Registration Dossier
Registration Dossier
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EC number: 201-075-4 | CAS number: 78-00-2
Toxicity to birds
Administrative data
Link to relevant study record(s)
Description of key information
It is proposed to waive this endpoint. Due to the already demonstrated high toxicity of the material in many other species, exposure of birds to TEL would result in their death before laying eggs. Therefore exposure to the bird food chain and subsequent generations of the bird chain is unlikely. Diehl et al also conclude in their study that there is no appreciable transfer of lead from the hen's organism to the egg.
Further testing on TEL for this endpoint would not enhance overall toxicity knowledge of substance and does not justify further animal testing.
Key value for chemical safety assessment
Additional information
It is proposed to waive this endpoint. Due to the already demonstrated high toxicity of the material in many other species, exposure of birds to TEL would result in their death before laying eggs. Therefore exposure to the bird food chain and subsequent generations of the bird chain is unlikely.
Diehl et al investigated the lead content of the muscles, gizzard, liver, bones and eggs of laying hens at sites near a plant emitting TEL. The sites were located at distances of 1000m, 1500m and outside the area of emissions (control). The brown hybrid hens were kept on small farms under free range husbandry. All hens were 20 weeks old at the beginning of the experiment. They were exposed for 0 (control), 6 or 12 months after which they were slaughtered and the lead contents determined. After 6 months, the tissue and organs of the hens at the nearest site showed signficantly higher lead contents than those further away. At this site, Pb concentrations were 1970 ug/kg (bone), 745 ug/kg (liver), 41 ug/kg (muscle) and 25 ug/kg (gizzard). After 12 months exposure only the bones and liver of the hens contained more lead than the animals at the two more distant sites.
It is concluded that there is no appreciable transfer of lead from the hen's organism to the egg.
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