Registration Dossier
Registration Dossier
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EC number: 201-075-4 | CAS number: 78-00-2
Biological effects monitoring
Administrative data
- Endpoint:
- biological effects monitoring
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Study well documented, meets generally accepted scientific principles, acceptable for assessment. Reliability assessment as per that quoted in IUCLID 4 (2000) data review
Data source
Reference
- Reference Type:
- publication
- Title:
- Studies of lead in tissues, organs and eggs of laying hens in the environment due to organo lead compounds
- Author:
- Diehl, K.H., Rosopulo, A., Kreuzer, W.
- Year:
- 1 985
- Bibliographic source:
- Archive for food hygiene, Vol 36, pp 113-116
Materials and methods
- Principles of method if other than guideline:
- Lead contents in tissues and organs as well as in eggs from laying hens in areas located near to TEL plants were determined by AA spectroscopy
Test material
- Reference substance name:
- Tetraethyllead
- EC Number:
- 201-075-4
- EC Name:
- Tetraethyllead
- Cas Number:
- 78-00-2
- Molecular formula:
- C8H20Pb
- IUPAC Name:
- tetraethylplumbane
Constituent 1
Results and discussion
Applicant's summary and conclusion
- Conclusions:
- It is concluded that there is no appreciable transfer of lead from the hen's organism to the egg.
- Executive summary:
Diehl et al investigated the lead content of the muscles, gizzard, liver, bones and eggs of laying hens at sites near a plant emitting TEL. The sites were located at distances of 1000m, 1500m and outside the area of emissions (control). The brown hybrid hens were kept on small farms under free range husbandry. All hens were 20 weeks old at the beginning of the experiment. They were exposed for 0 (control), 6 or 12 months after which they were slaughtered and the lead contents determined. After 6 months, the tissue and organs of the hens at the nearest site showed signficantly higher lead contents than those further away. At this site, Pb concentrations were 1970 ug/kg (bone), 745 ug/kg (liver), 41 ug/kg (muscle) and 25 ug/kg (gizzard). After 12 months exposure only the bones and liver of the hens contained more lead than the animals at the two more distant sites.
It is concluded that there is no appreciable transfer of lead from the hen's organism to the egg.
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