Registration Dossier
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EC number: 203-687-7 | CAS number: 109-61-5
Biodegradation in water: screening tests
Administrative data
Link to relevant study record(s)
Description of key information
The parent compound propyl chloroformate (CAS 109-61-5) is rapidly
hydrolysed (half-life = 29.5 min)
The hydrolysis product propanol (CAS 71-23-8) is readily biodegradable
according to OECD criteria.
Key value for chemical safety assessment
- Biodegradation in water:
- readily biodegradable
Additional information
QSAR-disclaimer
In Article 13 of Regulation (EC) No 1907/2006, it is laid down that information on intrinsic properties of substances may be generated by means other than tests, provided that the conditions set out in Annex XI (of the same Regulation) are met.
According to Annex XI of Regulation (EC) No 1907/2006 (Q)SAR results can be used if (1) the scientific validity of the (Q)SAR model has been established, (2) the substance falls within the applicability domain of the (Q)SAR model, (3) the results are adequate for the purpose of classification and labeling and/or risk assessment and (4) adequate and reliable documentation of the applied method is provided.
The criteria listed in Annex XI of Regulation (EC) No 1907/2006 are considered to be adequately fulfilled and, therefore, the endpoint(s) sufficiently covered and suitable for risk assessment.
Assessment
The parent compound propyl chloroformate is rapidly hydrolysed to propanol, HCl and CO2 (half-life = 29.5 min).
The biodegradation of propanol (CAS 71-23-8) in water was estimated using the QSAR method of CATALOGIC 301C v12.17 (OASIS Catalogic v5.15.2), which predicted an O2-consumption (BOD) of 100% after 28d (BASF, 2022). The substance is completely within the applicability domain of the model.
In a supporting closed bottle test (Standard Methods for the Examination of Water and Wastewater. 1971. 13th Ed. American Public Health Association, New York, NY) the degradation potential of the hydrolysis product propanol (CAS 71-23-8) was investigated using domestic activated sludge as inoculum. After 20 days, the degree of biodegradation was 75% O2 consumption (Price et al, 1974; EC, 2008).
Based on this result, the hydrolysis product propanol is considered readily biodegradable according to OECD criteria.
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