m-toluidine

Guidance on Safe Use

First-aid measures

INHALATION:

Get medical attention immediately. Move exposed person to fresh air. Keep person warm and at rest. If not breathing, if breathing is irregular or if respiratory arrest occurs, provide artificial respiration or oxygen by trained personnel. It may be dangerous to the person providing aid to give mouth-to-mouth resuscitation. If unconscious, place in recovery position and get medical attention immediately. Maintain an open airway. Loosen tight clothing such as a collar, tie, belt or waistband. In case of inhalation of decomposition products in a fire, symptoms may be delayed. The exposed person may need to be kept under medical surveillance for 48 hours.

INGESTION:

Get medical attention immediately. Wash out mouth with water. Move exposed person to fresh air. Keep person warm and at rest. If material has been swallowed and the exposed person is conscious, give small quantities of water to drink. Stop if the exposed person feels sick as vomiting may be dangerous. Do not induce vomiting unless directed to do so by medical personnel. If vomiting occurs, the head should be kept low so that vomit does not enter the lungs. Never give anything by mouth to an unconscious person. If unconscious, place in recovery position and get medical attention immediately. Maintain an open airway. Loosen tight clothing such as a collar, tie, belt or waistband.

SKIN CONTACT:

Get medical attention immediately. Remove contaminated clothing and shoes. Wash the skin immediately with plenty of soap and water; cleaning immediately with polyethyleneglycol 400 and washing subsequently with plenty of soap and water would be more effective. In case of blueness of lips, skin or nails (cyanosis) let the person breathe oxygen. No physical exertion. No consumption of alcohol after product contact. Carefully clean hair, under the nails, and other hidden areas. Wash clothing before reuse. Clean shoes thoroughly before reuse.

EYE CONTACT:

Get medical attention immediately. Immediately flush eyes with plenty of water, occasionally lifting the upper and lower eyelids. Check for and remove any contact lenses. Continue to rinse for at least 10 minutes.

NOTES TO THE PHYSICIAN:

Elementary aid, decontamination, symptomatic treatment and depending on the formation of methaemoglobin: intravenous administration of toluidine blue or other redox dyes according to dosage specifications plus ascorbic acid.

Fire-fighting measures

EXTINGUISHING MEDIA

Suitable: Use dry chemical, CO2, water spray (fog) or foam.

Not suitable: Do not use water jet.

SPECIAL EXPOSURE HAZARDS:

Combustible liquid. In a fire or if heated, a pressure increase will occur and the container may burst, with the risk of a subsequent explosion.

Promptly isolate the scene by removing all persons from the vicinity of the incident if there is a fire. No action shall be taken involving any personal risk or without suitable training. Move containers from fire area if this can be done without risk. Use water spray to keep fire-exposed containers cool. This material is very toxic to aquatic organisms. Fire water contaminated with this material must be contained and prevented from being discharged to any waterway, sewer or drain.

HAZARDOUS COMBUSTION PRODUCTS

Decomposition products may include the following materials:

carbon oxides

nitrogen oxides

SPECIAL PROTECTIVE EQUIPMENT FOR FIRE-FIGHTERS:

Fire-fighters should wear appropriate protective equipment and selfcontained breathing apparatus (SCBA) with a full face-piece operated in positive pressure mode.

Accidental release measures

PERSONAL PRECAUTIONS:

No action shall be taken involving any personal risk or without suitable training. Evacuate surrounding areas. Keep unnecessary and unprotected personnel from entering. Do not touch or walk through spilt material. Shut off all ignition sources. No flares, smoking or flames in hazard area. Avoid breathing vapour or mist. Provide adequate ventilation. Put on appropriate personal protective equipment.

ENVIRONMENTAL PRECAUTIONS:

Avoid dispersal of spilt material and runoff and contact with soil, waterways, drains and sewers. Inform the relevant authorities if the product has caused environmental pollution (sewers, waterways, soil or air). Very toxic to aquatic organisms.

LARGE SPILL:

Stop leak if without risk. Move containers from spill area. Prevent entry into sewers, water courses, basements or confined areas. Contain and collect spillage with non-combustible, absorbent material e.g. sand, earth, vermiculite or diatomaceous earth and place in container for disposal according to local regulations. Use spark-proof tools and explosion-proof equipment. Dispose of via a licensed waste disposal contractor. Contaminated absorbent material may pose the same hazard as the spilt product.

SMALL SPILL:

Stop leak if without risk. Move containers from spill area. Dilute with water and mop up if water-soluble or absorb with an inert dry material and place in an appropriate waste disposal container. Use spark-proof tools and explosion-proof equipment. Dispose of via a licensed waste disposal contractor.

Handling and storage

This substance is handled under Strictly Controlled Conditions in accordance with REACH regulation Article 17(3) for on-site isolated intermediates and, in case the substance is transported to other sites for further processing, the substance should be handled at these sites under the Strictly Controlled Conditions as specified in REACH regulation Article 18(4). Site  documentation to support safe handling arrangements including the selection of engineering, administrative and personal protective equipment controls in accordance with risk-based management systems is available at each Manufacturing site.

Written confirmation of application of Strictly Controlled Conditions has been received from every affected Distributor and Downstream Manufacturer/User of the Registrant's intermediate

HANDLING:

Put on appropriate personal protective equipment. Eating, drinking and smoking should be prohibited in areas where this material is handled, stored and processed. Workers should wash hands and face before eating, drinking and smoking. Do not get in eyes or on skin or clothing. Do not breathe vapour or mist. Do not ingest. Avoid release to the environment. Use only with adequate ventilation. Wear appropriate respirator when ventilation is inadequate. Do not enter storage areas and confined spaces unless adequately ventilated. Keep in the original container or an approved alternative made from a compatible material, kept tightly closed when not in use. Store and use away from heat, sparks, open flame or any other ignition source. Use explosion-proof electrical (ventilating, lighting and material handling) equipment. Use nonsparking tools. Take precautionary measures against electrostatic discharges. To avoid fire or explosion, dissipate static electricity during transfer by earthing and bonding containers and equipment before transferring material. Empty containers retain product residue and can be hazardous.

STORAGE:

Store in accordance with local regulations. Store in a segregated and approved area. Store in original container protected from direct sunlight in a dry, cool and well-ventilated area, away from incompatible materials and food and drink. Eliminate all ignition sources. Separate from oxidizing materials. Keep container tightly closed and sealed until ready for use. Containers that have been opened must be carefully resealed and kept upright to prevent leakage. Do not store in unlabelled containers. Use appropriate containment to avoid environmental contamination.

PACKAGING MATERIALS

Recommended: Use original container.

Remarks: Vent waste air only via suitable separators or scrubbers.

Transport information

Land transport (UN RTDG/ADR/RID)

UN number:

UN 1708

Shipping information

Proper shipping name and description:

toluidines, liquid

Chemical name:

m-toluidine

Language:

English

Labels:

Toxic

SpecialProvisions

Inland waterway transport (UN RTDG/ADN(R))

UN number:

UN 1708

Shipping information

Proper shipping name and description:

toluidines, liquid

Chemical name:

m-toluidine

Language:

English

Labels:

Toxic

Remarks

Marine transport (UN RTDG/IMDG)

UN number:

UN 1708

Shipping information

Proper shipping name and description:

Proper shipping name and description: toluidines, liquid

Chemical name:

m-toluidine

Labels:

Toxic

Remarks

Air transport (UN RTDG/ICAO/IATA)

UN number:

UN 1708

Shipping information

Proper shipping name and description:

toluidines, liquid

Chemical name:

m-toluidine

Labels:

Toxic

Special provisions / remarks

Remarks:

Passenger aircraft: 609: 5 L
Carco aircraft: 611: 60 L

Additional transport information

Additional information

Special provisions / remarks / other:

Toxic.
Combustible.
Flash point (Closed cup): 85 °C
Keep separated from foodstuffs.

Exposure controls / personal protection

This substance is handled under Strictly Controlled Conditions in accordance with REACH regulation Article 17(3) for on-site isolated intermediates and, in case the substance is transported to other sites for further processing, the substance should be handled at these sites under the Strictly Controlled Conditions as specified in REACH regulation Article 18(4). Site  documentation to support safe handling arrangements including the selection of engineering, administrative and personal protective equipment controls in accordance with risk-based management systems is available at each Manufacturing site.

Written confirmation of application of Strictly Controlled Conditions has been received from every affected Distributor and Downstream Manufacturer/User of the Registrant's intermediate

RECOMMENDED MONITORING PROCEDURES:

If this product contains ingredients with exposure limits, personal, workplace atmosphere or biological monitoring may be required to determine the effectiveness of the ventilation or other control measures and/or the necessity to use respiratory protective equipment. Reference should be made to European Standard EN 689 for methods for the assessment of exposure by inhalation to chemical agents and national guidance documents for methods for the determination of hazardous substances.

RISK MANAGEMENT MEASURES- OCCUPATIONAL EXPOSURE CONTROL

TECHNICAL MEASURES:

Use only with adequate ventilation. Use process enclosures, local exhaust ventilation or other engineering controls to keep worker exposure to airborne contaminants below any recommended or statutory limits. The engineering controls also need to keep gas, vapour or dust concentrations below any lower explosive limits. Use explosion-proof ventilation equipment.

The substance shall be rigorously contained by technical means during its whole lifecycle including manufacture, purification, cleaning and maintenance of equipment, sampling, analysis, loading and unloading of equipment or vessels, waste disposal or purification and storage. Procedural and control technologies shall be used that minimise emission and any resulting exposure. In cases of accident and where waste is generated, procedural and/or control technologies shall be used to minimise emissions and the resulting exposure during purification or cleaning and maintenance procedures.

ORGANISATIONAL MEASURES:

Only properly trained and authorised personnel shall handle the substance. In the case of cleaning and maintenance works, special procedures such as purging and washing shall be applied before the system is opened and entered. Only properly trained and authorised personnel shall handle the substance.

RISK MANAGEMENT MEASURES- PERSONAL PROTECTION MEASURE

RESPIRATORY PROTECTION

Use a properly fitted, air-purifying or air-fed respirator complying with an approved standard if exposure can not be excluded, e.g. during transfer of the product, sampling or maintenance. Respirator selection must be based on known or anticipated exposure levels, the hazards of the product and the safe working limits of the selected respirator.

Recommended: Combination filter, e.g. DIN 3181 ABEK or selfcontained breathing apparatus (SCBA

HAND PROTECTION

Chemical-resistant, impervious gloves complying with an approved standard should be worn at all times when handling chemical products if a risk assessment indicates this is necessary. After contamination with product change the gloves immediately and dispose of them according to relevant national and local regulations <1 hours (breakthrough time): Butyl rubber - IIR , Polychloroprene - CR, Fluorinated rubber - FKM, Nitrile rubber - NBR or Polyvinyl chloride - PVC

EYE PROTECTION

Safety eyewear complying with an approved standard should be used when a risk assessment indicates this is necessary to avoid exposure to liquid splashes, mists, gases or dusts. Recommended: Tightly fitting safety goggles.

SKIN PROTECTION

Wear protective clothing. Personal protective equipment for the body should be selected based on the task being performed and the risks involved and should be approved by a specialist before handling this product.

HYGIENE MEASURES

Wash hands, forearms and face thoroughly after handling chemical products, before eating, smoking and using the lavatory and at the end of the working period. Appropriate techniques should be used to remove potentially contaminated clothing. Wash contaminated clothing before reusing. Ensure that eyewash stations and safety showers are close to the workstation location.

ENVIRONMENTAL EXPOSURE CONTROLS- TECHNICAL MEASURES

TECHNICAL MEASURES

Emissions from ventilation or work process equipment should be checked to ensure they comply with the requirements of environmental protection legislation. In some cases, fume scrubbers, filters or engineering modifications to the process equipment will be necessary to reduce emissions to acceptable levels.

Stability and reactivity

STABILITY:

The product is stable.

CONDITIONS OT AVOID:

Avoid all possible sources of ignition (spark or flame). Do not pressurise, cut, weld, braze, solder, drill, grind or expose containers to heat or sources of ignition. Avoid release to the environment.

HAZARDOUS COMBUSTION PRODUCTS:

Under normal conditions of storage and use, hazardous decomposition products should not be produced.

Disposal considerations

METHODS OF DISPOSAL:

Examine possibilities for re-utilisation. Product residues and uncleaned empty containers should be packaged, sealed, labelled, and disposed of or recycled according to relevant national and local regulations. Where large quantities are concerned, consult the supplier. When uncleaned empty containers are passed on, the recipient must be warned of any possible hazard that may be caused by residues. For disposal within the EC, the appropriate code according to the European Waste List (EWL) should be used. It is among the tasks of the polluter to assign the waste to waste codes specific to industrial sectors and processes according to the European Waste List (EWL).

HAZARDOUS WASTE:

The classification of the product may meet the criteria for a hazardous waste.