Registration Dossier
Registration Dossier
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EC number: 203-583-1 | CAS number: 108-44-1
Dermal absorption
Administrative data
- Endpoint:
- dermal absorption in vivo
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- secondary literature
Data source
Referenceopen allclose all
- Reference Type:
- publication
- Title:
- Toxicodynamic properties of toluidines
- Author:
- Senczuk W, Rucinska H, Zak P cited in IUCLID data set of the European Commission
- Year:
- 2 000
- Bibliographic source:
- Bromat Chem Toksykol 17, 109-111, 1984
- Title:
- No information
- Author:
- Senczuk et al 1984 cited in IUCLID dataset
- Year:
- 2 000
- Bibliographic source:
- Bromat. Chem. Toksykol17, 241-243
Materials and methods
- Principles of method if other than guideline:
- Single dermal application to the tail of rats in a further study application of 2.5-12.5 mg/ml for 2-6 hours.
- GLP compliance:
- no
Test material
- Reference substance name:
- m-toluidine
- EC Number:
- 203-583-1
- EC Name:
- m-toluidine
- Cas Number:
- 108-44-1
- Molecular formula:
- C7H9N
- IUPAC Name:
- 3-methylaniline
- Test material form:
- other: liquid
- Details on test material:
- no further data
Constituent 1
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- no data
Administration / exposure
- Type of coverage:
- not specified
- Vehicle:
- not specified
- No. of animals per group:
- no data
- Details on study design:
- Single dermal application to the tail of rats. In a further study application of 2.5-12.5 mg/ml for 2-6 hours.
Results and discussion
- Signs and symptoms of toxicity:
- yes
- Absorption in different matrices:
- m-toluidiend was detected in the blood plasma of rats after dermal application. The plasma level correlated with the dose level (no further informatrion).
Methemoglobin concentrations up to 40 % were detected in the blood of rats after dermal exposure (2.5-12.5 mg/ml) for 2-6 hours (no further details available).
Applicant's summary and conclusion
- Executive summary:
m-toluidine was detected in the blood plasma of rats after dermal application. The plasma level correlated with the dose level (no further informatrion). Methemoglobin concentrations up to 40 % were detected in the blood of rats after dermal exposure (2.5-12.5 mg/ml) for 2-6 hours (no further details available).
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