Registration Dossier
Registration Dossier
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EC number: 203-583-1 | CAS number: 108-44-1
Genetic toxicity: in vivo
Administrative data
- Endpoint:
- in vivo mammalian cell study: DNA damage and/or repair
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: reporting insufficient for assessment
Data source
Reference
- Reference Type:
- publication
- Title:
- Sister chromatid exchange assay in BALB/c mice bone marrow under the influence of carcinogenic and non-carcinogenic products and half-finished products from dyestuff industry
- Author:
- Gorecka-Turska, D. et al.,
- Year:
- 1 983
- Bibliographic source:
- Bromat. Chem. Toksykol. XVI 1,|37-42
Materials and methods
- Principles of method if other than guideline:
- No data
- GLP compliance:
- not specified
- Type of assay:
- sister chromatid exchange assay
Test material
- Reference substance name:
- m-toluidine
- EC Number:
- 203-583-1
- EC Name:
- m-toluidine
- Cas Number:
- 108-44-1
- Molecular formula:
- C7H9N
- IUPAC Name:
- 3-methylaniline
- Details on test material:
- no data on purity
Constituent 1
Test animals
- Species:
- mouse
- Strain:
- Balb/c
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- no data
Administration / exposure
- Route of administration:
- intraperitoneal
- Vehicle:
- DMSO
- Details on exposure:
- no data
- Duration of treatment / exposure:
- once
- Frequency of treatment:
- once
- Post exposure period:
- no data
Doses / concentrations
- Remarks:
- Doses / Concentrations:
10, 50, 100 and 200 mg/kg b.w.
Basis:
- No. of animals per sex per dose:
- no data
- Control animals:
- yes, concurrent vehicle
- Positive control(s):
- no data
Examinations
- Details of tissue and slide preparation:
- no data
- Evaluation criteria:
- no data
- Statistics:
- no data
Results and discussion
Test results
- Sex:
- not specified
- Genotoxicity:
- negative
- Toxicity:
- not specified
- Vehicle controls validity:
- valid
- Negative controls validity:
- valid
- Positive controls validity:
- not specified
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
