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EC number: 943-030-8
CAS number: -
Individual skin irritation reactions.
* total = sum of 24 and 72 hour values
s = treatment area stained brown by test
The skin irritation potential of the test
item was evaluated in an experimental procedure comparable to OECD
Guideline 404 (1981). 0.5 g of undiluted, solid test item was applied to
the clipped, dorsal area of 3 female New Zealand albino rabbits and
secured for a duration of 4 hours with an occlusive dressing. The
surrounding skin of the test animal was considered a negative
control. Animals were then monitored for erythema (score out of 4),
oedema (score out of 4), corrosion, clinical symptoms and discolouration
at 1, 24, 48 and 72 hours after removal of the test item and dressing.
No clinical symptoms, irritation or
corrosion was observed during the test period, so the study was
terminated at 72 hours. No erythema or oedema was observed during the
study period, and irritation scores (mean 24, 48 and 72 hours) were 0
for both erythema and oedema in all three animals. In the area of
application, slight brown staining of
the treated skin by pigment or colouring by the test
item was observed at 48, 24 and 72 hours in test subjects #1, #2 and #3,
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