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EC number: 943-030-8
CAS number: -
NOEC (72 and 96 hours, Scenedesmus
subspicatus) = 20 mg/l (nominal)
The toxicity of the test item to aquatic
algae was evaluated in a 96-hour experimental study on Scenedesmus
subspicatus according to the OECD Guideline 201 (1984). 10 000
cells/ml cultivation of S. subspicatus were exposed to test item
concentrations of 0.3125, 1.25, 5.0, 20 and 80 mg/l and cells were
counted after 24, 48, 72 and 96 hours. Change in cell count over time
was represented graphically to form dose-response curves for each
concentration, and toxicity was analysed by comparison of the area under
respective growth curves of treated and untreated samples. A positive
control (potassium dichromate) was also tested in parallel. pH was
adjusted to 7.7 ± 0.3 at the start of the test using HCl, then monitored
at the end of the study period. Stability of the test item in test media
was evaluated by comparison of nominal and measured test item
concentration at the start and end of the study period (0 and 96 hours).
EbC50 was measured using the LOGIT-Model, and the NOEC and LOEC were
evaluated using the dose-response curve.
Only EbC50 (72 h and 96 h) were reported
in the study report. Based on the available data on number of cell at
the different time points, a range of the percentage of inhibition
considering the growth rate is calculated. The ErC50 (96 h) is expected
to be between 20 -80 mg/L (% inhibition at 20 mg/L and 80 mg/L is ca. 5
% and 70 % respectively). It is worth noting that the evaluation of the
toxicity potential of the substance to algae presents some limits due to
the nature of the substance (dye). Specifically, it cannot be
distinguished whether the effects are due to the colour of the test item
(and hence the coloured test medium) or they are due to an intrinsic
Based on the read across consideations same
results apply to the target substance.
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