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EC number: 943-030-8
CAS number: -
Table 1: Mortality and signs of
reaction in test animals administered a single dose of the test item.
Table 2: Individual body weights of
male and female test animals.
* animal died during study
Table 3: Individual findings at
* animal died during study
The acute oral toxicity of the substance
was evaluated in an experimental study performed according to a
procedure similar to the OECD Guideline 401 (1981). The test item was
administered to male and female Sprague-Dawley rats of both sexes by
oral gavage, at doses of 4000 and 5000 mg/kg bw (5 female and 5 male
animals per dose). Animals were then monitored for mortality, clinical
symptoms and body weight changes for 15 days. At the end of the study
period, all remaining animals were sacrificed and subjected to gross
pathological examination at necropsy.
No mortality was observed in the group
administered 4000 mg/kg bw. 1 male animal died in the group administered
5000 mg/kg bw on the day following administration of the test item. No
further mortality occurred until the end of the study period (14 days)
when all animals were sacrificed. All animals administered 4000 mg/kg bw
demonstrated black staining around the anus on the day following
administration. This symptom continued to the next day for 3 of these
animals. On days 1 and 2 following administration, one animal
demonstrated emaciation, and one animal demonstrated hunched posture (a
typical symptom of pain). One animal demonstrated piloerection 2 days
after administration. From day 3 after administration, no symptoms were
observed in this group until the end of the study period. No clinical
signs were observed among the 9 surviving animals administered 5000
mg/kg bw. All surviving animals showed comparable body weight gain at
the end of the study period. One male and one female from the group
administered 5000 mg/kg bw test item demonstrated dark red patches in
all lobes of the lungs; one male animal demonstrated dark red patches in
all lobes of the lungs and light patches on the liver; and 7 animals
demonstrated no abnormalities. In the group administered 4000 mg/kg bw
test item, no abnormalities were observed. Based on these findings, the
acute oral toxicity of the test item in rats of both sexes, observed
over a period of 15 days, was estimated to be: greater than 5000 mg/kg
bw. Therefore, it can be extrapolated that the LD50 (oral, rat) is
greater than 5000 mg/kg bw.
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